اکثر مکاتبات کومش از طریق ایمیل سایت می باشد.
لطفا Spam ایمیل خود را نیز چک نمایید.
   [Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 7, Issue 3 (8-2006) ::
koomesh 2006, 7(3): 153-158 Back to browse issues page
The effect of long-term oral administration of Nigella. sativum on the contractile reactivity of thoracic aorta in diabetic rats
M. Roghani , T. Baluchnejadmojarad, M.R. Vaez-Mahdavi, M. Vasei
Abstract:   (12150 Views)
Introduction: Therapeutics, especially medical plants with minimum side-effects are of high value in preventing vascular complications of diabetes mellitus in long term. Considering the evidences about the anti-diabetic effects of Nigella. Sativum (NS), the current study was conducted to evaluate the effect of oral two-month administration of NS on the contractile reactivity of isolated aorta in male diabetic rats. Material & Methods: Male Wistar rats (n=32) were randomly divided into control, NS-treated control, diabetic, and NS-treated diabetic groups. For induction of diabetes, streptozotcin (STZ) was intraperitoneally administered. The treatment groups were received oral administration of NS-mixed pelleted food (6.25%) for two months. After two months, the contractile reactivity of aortic rings to KCl and noreadrenaline was determined using isolated tissue setup. Results: Contractile response to cumulative KCl and noreadrenaline followed a dose-dependent pattern in aortic rings in all groups. In addition, the maximum contractile reactivity was significantly higher in the diabetic group compared to the control one (p<0.001). Meanwhile, this response was lower in NS-treated diabetic group in comparison with untreated diabetic group (p<0.05). Conclusion: Long-term oral administration of Nigella. sativum attenuated the enhanced vascular responsiveness in diabetes mellitus and some developed cardiovascular complications due to diabetes.
Keywords: Nigella sativum, Vascular System, Diabetes Mellitus, Contractile Response, Rat
Full-Text [PDF 200 kb]   (1610 Downloads)    
Type of Study: Applicable | Subject: General
Received: 2008/09/6
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Roghani M, Baluchnejadmojarad T, Vaez-Mahdavi M, Vasei M. The effect of long-term oral administration of Nigella. sativum on the contractile reactivity of thoracic aorta in diabetic rats. koomesh. 2006; 7 (3) :153-158
URL: http://koomeshjournal.semums.ac.ir/article-1-95-en.html


Volume 7, Issue 3 (8-2006) Back to browse issues page
کومش Koomesh
Persian site map - English site map - Created in 0.05 seconds with 32 queries by YEKTAWEB 3991