:: Volume 13, Issue 1 ( (پياپی 41)، پائيز 1390) ::
Koomesh 1390, 13(1): 100-107 Back to browse issues page
Effects of mecamylamine (a nicotinic receptor antagonist) on harman induced-amnesia in an inhibitory avoidance test
Mohammad ناصحی , Morteza پیری , Shahrbano شریفی , Maryam-sadat شاهین , Mohammad Reza زرین دست
Abstract:   (14276 Views)
  Introduction: β-carbolines alkaloids suchv as harmane have been found in common plant-derived foodstuffs (wheat, rice, corn, barley, grape and mushrooms). These alkaloids have many cognitive effects including alteration short and long term memory. In the present study, the effect of intra-CA1 injection of the nicotinic receptor antagonist mecamylamine on amnesia induced by harmane was examined in mice.   Materials and Methods: Mice were bilaterally implanted with chronic cannulae in the CA1 regions of the dorsal hippocampus. One week after cannulae implantation, mice were trained in a step-down type inhibitory avoidance task, and were tested 24 h after training to measure step-down latency as a scale of memory.   Results: Pre-training or post-training systemic injection of harmane induced amnesia. Pre-testing intra-dorsal hippocampus administration of the high dose of nicotinic receptor antagonist, mecamylamine (4 µg/mice) also induced amnesia. On the other hand, pre-test intra-CA1 injection of ineffective doses of mecamylamine (0.5, 1 and 2 µg/mice) fully restored harmane induced amnesia.   Conclusion: The present finding in this study indicated that a complex interaction exists between nicotinic receptor of dorsal hippocampus and amnesia induced by Harmane.  
Keywords: Harmane, Mecamylamine, Amnesia, Dorsal hippocampus, Mice
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Type of Study: Research | Subject: General
Received: 2010/07/11 | Accepted: 2015/02/4 | Published: 2015/02/4


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Volume 13, Issue 1 ( (پياپی 41)، پائيز 1390) Back to browse issues page