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:: Volume 13, Issue 1 (Autumn 2011, 13 (1): 1- 141 2011) ::
koomesh 2011, 13(1): 100-107 Back to browse issues page
Effects of mecamylamine (a nicotinic receptor antagonist) on harman induced-amnesia in an inhibitory avoidance test
Mohammad Nasehi , Morteza Piri, Shahrbano Sharifi, Maryam-sadat Shahin, Mohammad Reza Zarrindast
Abstract:   (11170 Views)

  Introduction: β-carbolines alkaloids suchv as harmane have been found in common plant-derived foodstuffs (wheat, rice, corn, barley, grape and mushrooms). These alkaloids have many cognitive effects including alteration short and long term memory. In the present study, the effect of intra-CA1 injection of the nicotinic receptor antagonist mecamylamine on amnesia induced by harmane was examined in mice.

  Materials and Methods: Mice were bilaterally implanted with chronic cannulae in the CA1 regions of the dorsal hippocampus. One week after cannulae implantation, mice were trained in a step-down type inhibitory avoidance task, and were tested 24 h after training to measure step-down latency as a scale of memory.

  Results: Pre-training or post-training systemic injection of harmane induced amnesia. Pre-testing intra-dorsal hippocampus administration of the high dose of nicotinic receptor antagonist, mecamylamine (4 µg/mice) also induced amnesia. On the other hand, pre-test intra-CA1 injection of ineffective doses of mecamylamine (0.5, 1 and 2 µg/mice) fully restored harmane induced amnesia.

  Conclusion: The present finding in this study indicated that a complex interaction exists between nicotinic receptor of dorsal hippocampus and amnesia induced by Harmane.

 

Keywords: Harmane, Mecamylamine, Amnesia, Dorsal hippocampus, Mice
Full-Text [PDF 524 kb]   (1565 Downloads)    
Type of Study: Research | Subject: General
Received: 2010/07/11 | Accepted: 2015/02/4 | Published: 2015/02/4
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nasehi M, Piri M, Sharifi S, shahin M, zarrindast M R. Effects of mecamylamine (a nicotinic receptor antagonist) on harman induced-amnesia in an inhibitory avoidance test . koomesh. 2011; 13 (1) :100-107
URL: http://koomeshjournal.semums.ac.ir/article-1-876-en.html


Volume 13, Issue 1 (Autumn 2011, 13 (1): 1- 141 2011) Back to browse issues page
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