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Comparing the Therapeutic effects of Myrtenol's Simple and Niosomal Forms in Lung Ischemia Reperfusion Injury
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Mohammad Abbas Bejeshk   , Gholamreza Sepehri , Hamid Najafipour , Mohammad Khaksari , Mohammad Hadi Nematollahi , Shahriar Dabiri , Mohammad Amin Rajizadeh |
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Abstract: (368 Views) |
Introduction: Ischemia-reperfusion injury is directly related to forming reactive oxygen species, endothelial cell injury, increased vascular permeability, and the activation of neutrophils and cytokines. Niosomes are nanocarriers and an essential part of drug delivery systems. We aimed to investigate the effects of myrtenol's inhaled niosomal form, compared to its simple form, on lung Ischemia-reperfusion injury.
Methods and Material: Wistar rats were divided into four groups. Sham group, lung Ischemia Reperfusion (they were subjected to ischemia for 60 minutes and reperfusion for 120 minutes), Simple form of Myrtenol+LIR, Niosomal form of Myrtenol+LIR. Simple and niosomal forms of myrtenol were inhaled daily for one week prior to LIR. We evaluated oxidative stress (including Catalase, Superoxide Dismutase, Glutathione Peroxidase, Malondialdehyde, Total Oxidant Status, and Total Antioxidant Capacity), apoptosis (bcl-2-like protein 4 and B-cell lymphoma 2) and inflammation (Tumor necrosis factor alpha, Interleukin-17 and Interleukin-6) and histopathological indices (Wet/Dry weight Ratio, congestion of capillaries, neutrophil infiltration, and bleeding in the alveoli).
Results: Pretreatment with simple and niosomal forms of myrtenol significantly inhibited the histopathological indices, pro-inflammatory cytokines, Oxidative stress agents, apoptotic proteins. Furthermore, myrtenol increased Anti-inflammatory cytokines, Anti-Oxidants agents and antiapoptotic proteins. The niosomal form of myrtenol showed a more ameliorative effect than its simple form.
Conclusion: The results showed the superior protective effect of the inhalation of its niosomal form against LIRI compared to its simple form.
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| Keywords: lung ischemia-reperfusion injury, myrtenol, niosome, oxidative stress, inflammatory factors |
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Full-Text [PDF 278 kb]
(63 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/01/17 | Accepted: 2023/08/23 | Published: 2023/08/23
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