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:: Volume 11, Issue 3 (Spring 2010. Vol. 11 No. 3, 2010) ::
koomesh 2010, 11(3): 215-220 Back to browse issues page
Comparison of artificial neural network and Cox regression models in survival prediction of gastric cancer patients
Akbar Biglarian, Ebrahim Hajizadeh , Anoshirvan Kazemnejad
Abstract:   (18458 Views)
Introduction: Cox regression model is one of the statistical methods in survival analysis. Proportionality of hazard rate is an assumption of this model. In the recent decades, artificial neural network (ANN) model has increasingly used in survival prediction. This study aimed to predict the survival probability of Gastric cancer patients using Cox regression and ANN models. Materials and Methods: In this historical-cohort study, information of total of 436 gastric cancer patients with adenocarcinomas pathology who underwent surgery at the Taleghani hospital of Tehran between 2002 and 2007 were included. Data were divided to training and testing (or validation) groups, randomly. The Cox regression model (semi-parametric model) and a three layer ANN model were used for analyzing of database. Furthermore, the area under receiver operating characteristic curve (AUROC) and classification accuracy were used to compare these models. Results: Prediction accuracy of ANN and Cox regression models were 81.51% and 72.60%, respectively. In addition, AUROC of ANN and Cox regression models were 0.826 and 0.754, respectively. Conclusions: ANN was better than Cox regression model in terms of AUROC and accuracy of prediction. Therefore, ANN model is recommended for prediction of survival probability. These finding are very important in health research, particularly in allocation of medical resources for patients who predicted as high-risks
Keywords: Artificial neural network, Survival analysis, Prediction, Cox regression, Gastric cancer
Full-Text [PDF 151 kb]   (8984 Downloads)    
Type of Study: Research | Subject: General
Received: 2010/03/17 | Accepted: 2015/02/9 | Published: 2015/02/9
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Biglarian A, Hajizadeh E, Kazemnejad A. Comparison of artificial neural network and Cox regression models in survival prediction of gastric cancer patients. koomesh. 2010; 11 (3) :215-220
URL: http://koomeshjournal.semums.ac.ir/article-1-741-en.html


Volume 11, Issue 3 (Spring 2010. Vol. 11 No. 3, 2010) Back to browse issues page
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