1. [1] Wang Y, Qian S, Meng G, Zhang S. Cloning and expression of L-asparaginase gene in Escherichia coli. Appl Biochem Biotechnol 2001; 95: 93-101. [DOI:10.1385/ABAB:95:2:093]

2. [2] Abshire T, Pollock B, Billett A, Bradley P, Buchanan G. Weekly polyethylene glycol conjugated (PEG) L-asparaginase (ASP) produces superior induction remission rates in childhood relapsed acute lymphoblastic leukemia (rALL): a Pediatric Oncology Group (POG) study 9310. in Proc Am Soc Clin Oncol 1995; 14: 344.

3. [3] Aljewari HS, Nader MI, Alfaisal AH. High efficiency, selectivity against cancer cell line of purified L-Asparaginase from pathogenic Escherichia coli. World Acad Sci Engin Technol 2010; 4: 199-204.

4. [4] Souza PM, de Freitas MM, Cardoso SL, Pessoa A, Guerra EN, Magalhaes PO. Optimization and purification of l-asparaginase from fungi: A systematic review. Crit Rev Oncol Hematol 2017; 120: 194-202. [DOI:10.1016/j.critrevonc.2017.11.006] [PMID]

5. [5] Vimal A, Kumar A, Biotechnological production and practical application of L-asparaginase enzyme. Biotechnol Genet Eng Rev 2017; 33: 40-61. [DOI:10.1080/02648725.2017.1357294] [PMID]

6. [6] Appel IM, van Kessel-Bakvis C, Stigter R, Pieters R. Influence of two different regimens of concomitant treatment with asparaginase and dexamethasone on hemostasis in childhood acute lymphoblastic leukemia. Leukemia 2007; 21: 2377. [DOI:10.1038/sj.leu.2404793] [PMID]

7. [7] Ashihara Y, Kono T, Yamazaki S, Inada Y. Modification of E. coli L-asparaginase with polyethylene glycol: disappearance of binding ability to anti-asparaginase serum. Biochem Biophys Res Commun 1978; 83: 385-391. [DOI:10.1016/0006-291X(78)91002-1]

8. [8] Lanvers-Kaminsky C. Asparaginase pharmacology: challenges still to be faced. Cancer Chemother Pharmacol 2017; 79: 439-450. [DOI:10.1007/s00280-016-3236-y] [PMID]

9. [9] Hosamani R, Kaliwal BB. L-asparaginase an anti-tumor agent production by Fusarium equiseti using solid state fermentation. Int J Drug Discover 2011; 3: 88-99. [DOI:10.9735/0975-4423.3.2.88-99]

10. [10] Boos J, Werber G, Ahlke E, Schulze-Westhoff P, Nowak-Göttl U, Würthwein G, et al. Monitoring of asparaginase activity and asparagine levels in children on different asparaginase preparations. Eur J Cancer 1996; 32A: 1544-1550. [DOI:10.1016/0959-8049(96)00131-1]

11. [11] Baskar G, Renganathan S. Optimization of L‐asparaginase production by Aspergillus terreus MTCC 1782 using response surface methodology and artificial neural network‐linked genetic algorithm. Asia‐Pacific J Chem Engin 2012; 7: 212-220. [DOI:10.1002/apj.520]

12. [12] Batool T, Makky EA, Jalal M, Yusoff MM. A Comprehensive Review on L-Asparaginase and Its Applications. Appl Biochem Biotechnol 2016; 178: 900-923. [DOI:10.1007/s12010-015-1917-3] [PMID]

13. [13] Eijsink VG, Gåseidnes S, Borchert TV, van den Burg B. Directed evolution of enzyme stability. Biomolecul Engin 2005; 22: 21-30. [DOI:10.1016/j.bioeng.2004.12.003] [PMID]

14. [14] Chow Y, Ting AS. Endophytic l-asparaginase-producing fungi from plants associated with anticancer properties. J Adv Res 2015; 6: 869-876. [DOI:10.1016/j.jare.2014.07.005] [PMID] [PMCID]

15. [15] Deshpande N, Choubey P, Agashe M. Studies on optimization of growth parameters for L-asparaginase production by Streptomyces ginsengisoli. Scientific World Journal 2014; 2014: 895167. [DOI:10.1155/2014/895167] [PMID] [PMCID]

16. [16] Erva RR, Goswami AN, Suman P, Vedanabhatla R, Rajulapati SB. Optimization of L-asparaginase production from novel Enterobacter sp., by submerged fermentation using response surface methodology. Prep Biochem Biotechnol 2017; 47: 219-228. [DOI:10.1080/10826068.2016.1201683] [PMID]

17. [17] Sambrook J. Molecular cloning: a laboratory manual. 2001, New York: Cold spring harbor laboratory press.

18. [18] Klis FM, de Jong M, Brul S, de Groot PW. Extraction of cell surface‐associated proteins from living yeast cells. Yeast 2007; 24: 253-258. [DOI:10.1002/yea.1476] [PMID]

19. [19] Cachumba JJ, Antunes FA, Peres GF, Brumano LP, Dos Santos JC, Da Silva SS. Current applications and different approaches for microbial l-asparaginase production. Braz J Microbiol 2016; 47: 77-85. [DOI:10.1016/j.bjm.2016.10.004] [PMID] [PMCID]

20. [20] Kotzia GA, Labrou NE. Cloning, expression and characterisation of Erwinia carotovora L-asparaginase. J Biotechnol 2005; 119: 309-323. [DOI:10.1016/j.jbiotec.2005.04.016] [PMID]

21. [21] Shakerimoghadam F, Dejamfekr M, Ghaffari SH, Ahmadian S, Khaleghian A. Arsenic trioxide induction autophagy in human acute promyelocytic leukemia. Koomesh 2018; 20: 764-771.

22. [22] Azizi SO, Tarinejad AL. Isolation, cloning and analysis of the glucose transporter gene 7 from Iranian strain of Saccharomyces cerevisiae. Koomesh 2015; 16: 356-365.

23. [23] Distasio JA, Niederman RA, Kafkewitz D, Goodman D. Purification and characterization of L-asparaginase with anti-lymphoma activity from Vibrio succinogenes. J Biol Chem 1976; 251: 6929-6933.

24. [24] Doriya K, Kumar DS. Isolation and screening of L-asparaginase free of glutaminase and urease from fungal sp. 3 Biotech. 2016; 6: 239. [DOI:10.1007/s13205-016-0544-1] [PMID] [PMCID]

25. [25] El-Bessoumy AA, Sarhan M, Mansour J. Production, isolation, and purification of L-asparaginase from Pseudomonas aeruginosa 50071 using solid-state fermentation. BMB Reports 2004; 37: 387-393. [DOI:10.5483/BMBRep.2004.37.4.387] [PMID]

26. [26] Krishnapura PR, Belur PD, Subramanya S. A critical review on properties and applications of microbial l-asparaginases. Crit Rev Microbiol 2016; 42: 720-737.

27. [27] Shrivastava A, Khan AA, Khurshid M, Kalam MA, Jain SK, Singhal PK. Recent developments in L-asparaginase discovery and its potential as anticancer agent. Crit Rev Oncol Hematol 2016; 100: 1-10. [DOI:10.1016/j.critrevonc.2015.01.002] [PMID]

28. [28] Albanese ER, Kafkewitz K. Effect of medium composition on the growth and asparaginase production of Vibrio succinogenes. Appl Environ Microbiol 1978; 36: 25-30. [DOI:10.1128/AEM.36.1.25-30.1978]

29. [29] Kumar NM, Ramasamy R, Manonmani HK. Production and optimization of l-asparaginase from Cladosporium sp. using agricultural residues in solid state fermentation. Industrial Crops Products 2013; 43: 150-158. [DOI:10.1016/j.indcrop.2012.07.023]

30. [1] Wang Y, Qian S, Meng G, Zhang S. Cloning and expression of L-asparaginase gene in Escherichia coli. Appl Biochem Biotechnol 2001; 95: 93-101. [DOI:10.1385/ABAB:95:2:093]

31. [2] Abshire T, Pollock B, Billett A, Bradley P, Buchanan G. Weekly polyethylene glycol conjugated (PEG) L-asparaginase (ASP) produces superior induction remission rates in childhood relapsed acute lymphoblastic leukemia (rALL): a Pediatric Oncology Group (POG) study 9310. in Proc Am Soc Clin Oncol 1995; 14: 344.

32. [3] Aljewari HS, Nader MI, Alfaisal AH. High efficiency, selectivity against cancer cell line of purified L-Asparaginase from pathogenic Escherichia coli. World Acad Sci Engin Technol 2010; 4: 199-204.

33. [4] Souza PM, de Freitas MM, Cardoso SL, Pessoa A, Guerra EN, Magalhaes PO. Optimization and purification of l-asparaginase from fungi: A systematic review. Crit Rev Oncol Hematol 2017; 120: 194-202. [DOI:10.1016/j.critrevonc.2017.11.006] [PMID]

34. [5] Vimal A, Kumar A, Biotechnological production and practical application of L-asparaginase enzyme. Biotechnol Genet Eng Rev 2017; 33: 40-61. [DOI:10.1080/02648725.2017.1357294] [PMID]

35. [6] Appel IM, van Kessel-Bakvis C, Stigter R, Pieters R. Influence of two different regimens of concomitant treatment with asparaginase and dexamethasone on hemostasis in childhood acute lymphoblastic leukemia. Leukemia 2007; 21: 2377. [DOI:10.1038/sj.leu.2404793] [PMID]

36. [7] Ashihara Y, Kono T, Yamazaki S, Inada Y. Modification of E. coli L-asparaginase with polyethylene glycol: disappearance of binding ability to anti-asparaginase serum. Biochem Biophys Res Commun 1978; 83: 385-391. [DOI:10.1016/0006-291X(78)91002-1]

37. [8] Lanvers-Kaminsky C. Asparaginase pharmacology: challenges still to be faced. Cancer Chemother Pharmacol 2017; 79: 439-450. [DOI:10.1007/s00280-016-3236-y] [PMID]

38. [9] Hosamani R, Kaliwal BB. L-asparaginase an anti-tumor agent production by Fusarium equiseti using solid state fermentation. Int J Drug Discover 2011; 3: 88-99. [DOI:10.9735/0975-4423.3.2.88-99]

39. [10] Boos J, Werber G, Ahlke E, Schulze-Westhoff P, Nowak-Göttl U, Würthwein G, et al. Monitoring of asparaginase activity and asparagine levels in children on different asparaginase preparations. Eur J Cancer 1996; 32A: 1544-1550. [DOI:10.1016/0959-8049(96)00131-1]

40. [11] Baskar G, Renganathan S. Optimization of L‐asparaginase production by Aspergillus terreus MTCC 1782 using response surface methodology and artificial neural network‐linked genetic algorithm. Asia‐Pacific J Chem Engin 2012; 7: 212-220. [DOI:10.1002/apj.520]

41. [12] Batool T, Makky EA, Jalal M, Yusoff MM. A Comprehensive Review on L-Asparaginase and Its Applications. Appl Biochem Biotechnol 2016; 178: 900-923. [DOI:10.1007/s12010-015-1917-3] [PMID]

42. [13] Eijsink VG, Gåseidnes S, Borchert TV, van den Burg B. Directed evolution of enzyme stability. Biomolecul Engin 2005; 22: 21-30. [DOI:10.1016/j.bioeng.2004.12.003] [PMID]

43. [14] Chow Y, Ting AS. Endophytic l-asparaginase-producing fungi from plants associated with anticancer properties. J Adv Res 2015; 6: 869-876. [DOI:10.1016/j.jare.2014.07.005] [PMID] [PMCID]

44. [15] Deshpande N, Choubey P, Agashe M. Studies on optimization of growth parameters for L-asparaginase production by Streptomyces ginsengisoli. Scientific World Journal 2014; 2014: 895167. [DOI:10.1155/2014/895167] [PMID] [PMCID]

45. [16] Erva RR, Goswami AN, Suman P, Vedanabhatla R, Rajulapati SB. Optimization of L-asparaginase production from novel Enterobacter sp., by submerged fermentation using response surface methodology. Prep Biochem Biotechnol 2017; 47: 219-228. [DOI:10.1080/10826068.2016.1201683] [PMID]

46. [17] Sambrook J. Molecular cloning: a laboratory manual. 2001, New York: Cold spring harbor laboratory press.

47. [18] Klis FM, de Jong M, Brul S, de Groot PW. Extraction of cell surface‐associated proteins from living yeast cells. Yeast 2007; 24: 253-258. [DOI:10.1002/yea.1476] [PMID]

48. [19] Cachumba JJ, Antunes FA, Peres GF, Brumano LP, Dos Santos JC, Da Silva SS. Current applications and different approaches for microbial l-asparaginase production. Braz J Microbiol 2016; 47: 77-85. [DOI:10.1016/j.bjm.2016.10.004] [PMID] [PMCID]

49. [20] Kotzia GA, Labrou NE. Cloning, expression and characterisation of Erwinia carotovora L-asparaginase. J Biotechnol 2005; 119: 309-323. [DOI:10.1016/j.jbiotec.2005.04.016] [PMID]

50. [21] Shakerimoghadam F, Dejamfekr M, Ghaffari SH, Ahmadian S, Khaleghian A. Arsenic trioxide induction autophagy in human acute promyelocytic leukemia. Koomesh 2018; 20: 764-771.

51. [22] Azizi SO, Tarinejad AL. Isolation, cloning and analysis of the glucose transporter gene 7 from Iranian strain of Saccharomyces cerevisiae. Koomesh 2015; 16: 356-365.

52. [23] Distasio JA, Niederman RA, Kafkewitz D, Goodman D. Purification and characterization of L-asparaginase with anti-lymphoma activity from Vibrio succinogenes. J Biol Chem 1976; 251: 6929-6933.

53. [24] Doriya K, Kumar DS. Isolation and screening of L-asparaginase free of glutaminase and urease from fungal sp. 3 Biotech. 2016; 6: 239. [DOI:10.1007/s13205-016-0544-1] [PMID] [PMCID]

54. [25] El-Bessoumy AA, Sarhan M, Mansour J. Production, isolation, and purification of L-asparaginase from Pseudomonas aeruginosa 50071 using solid-state fermentation. BMB Reports 2004; 37: 387-393. [DOI:10.5483/BMBRep.2004.37.4.387] [PMID]

55. [26] Krishnapura PR, Belur PD, Subramanya S. A critical review on properties and applications of microbial l-asparaginases. Crit Rev Microbiol 2016; 42: 720-737.

56. [27] Shrivastava A, Khan AA, Khurshid M, Kalam MA, Jain SK, Singhal PK. Recent developments in L-asparaginase discovery and its potential as anticancer agent. Crit Rev Oncol Hematol 2016; 100: 1-10. [DOI:10.1016/j.critrevonc.2015.01.002] [PMID]

57. [28] Albanese ER, Kafkewitz K. Effect of medium composition on the growth and asparaginase production of Vibrio succinogenes. Appl Environ Microbiol 1978; 36: 25-30. [DOI:10.1128/AEM.36.1.25-30.1978]

58. [29] Kumar NM, Ramasamy R, Manonmani HK. Production and optimization of l-asparaginase from Cladosporium sp. using agricultural residues in solid state fermentation. Industrial Crops Products 2013; 43: 150-158. [DOI:10.1016/j.indcrop.2012.07.023]