اکثر مکاتبات کومش از طریق ایمیل سایت می باشد.
لطفا Spam ایمیل خود را نیز چک نمایید.
   [Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 21, Issue 3 (Summer 2019) ::
koomesh 2019, 21(3): 540-548 Back to browse issues page
Effects of combined therapy with resveratrol, continuous and interval exercises on apoptosis and lipid profiles in the liver of rats with nonalcoholic fatty liver disease
Amir Haj Ghasem, Parvin Farzanegi , Zohreh Mazaheri
Abstract:   (683 Views)
Introduction: Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver disorders. In this study, effect of resveratrol supplementation alone or in combination with interval and continuous exercises was considered on hepatic cells apoptosis and serum lipid profiles in rats with NAFLD.
Materials and Methods: Old rats were divided into two groups, including control and NAFLD. The NAFLD rats were then randomly divided into seven experimental sub-groups including NAFLD, NAFLSD + saline, NAFLD + resveratrol (RSV), NAFLD + continuous exercise, NAFLD + interval exercise, NAFLD + continuous exercise + RSV, and NAFLD + interval exercise + RSV. Apoptosis biomarkers, including liver Bax and Bcl2 proteins, and serum lipid profiles including HDL, LDL, total cholesterol (Cho) and triglyceride (TG), were measured using specific ELISA kits.
Results: Resveratrol supplementation alone or in combination with exercise training significantly decreased the serum LDL, Cho and TG levels (p<0.05), but significantly increased the HDL level (p<0.05). RSV alone or in combination with interval and continuous exercise programs significantly decreased Bax protein content (p<0.001), but significantly increased the Bcl2 level (p<0.001).
Conclusion: NAFLD is powerfully associated with the liver cells apoptosis and abnormality in lipid profiles. Although, resveratrol supplementation alone has an anti-apoptotic and reducing effect on lipid profiles, the combined therapy with exercise training can be more effective
Keywords: Apoptosis, Oxidative Stress, Non-alcoholic Fatty Liver, Lipid, Exercise, Resveratrol
Full-Text [PDF 2127 kb]   (82 Downloads)    
Type of Study: Research | Subject: General
Received: 2018/05/1 | Accepted: 2018/10/24 | Published: 2019/06/16
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Haj Ghasem A, Farzanegi P, Mazaheri Z. Effects of combined therapy with resveratrol, continuous and interval exercises on apoptosis and lipid profiles in the liver of rats with nonalcoholic fatty liver disease. koomesh. 2019; 21 (3) :540-548
URL: http://koomeshjournal.semums.ac.ir/article-1-4794-en.html


Volume 21, Issue 3 (Summer 2019) Back to browse issues page
کومش Koomesh
Persian site map - English site map - Created in 0.1 seconds with 32 queries by YEKTAWEB 3977