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:: Volume 19, Number 3 ( Summer 2017, 19 (3). 505-711 2017) ::
koomesh 2017, 19(3): 619-625 Back to browse issues page
Lack of association between PstI polymorphism in the 3' flanking region of the apolipoprotein AI gene and serum lipids levels in an Iranian population
Abbas Pakdel, Mohammad Reza Akbari eydgahi, Ahmad Reza Bandegi *
Abstract:   (180 Views)

Introduction: ApoAI, is the main protein of HDL and its gene is a member of apoAI-CIII-AIV gene cluster on chromosome 11q23-q24. In some studies, association of PstI polymorphism with dyslipidemia has been reported. This study was designed to investigate the frequency of rare allele (P2) of apoAI gene PstI polymorphism and its association with serum lipids levels in an Iranian population (Semnan city).

Materials and Methods: In a case-control study genomic DNA was extracted from whole blood of 76 Iranian hyperlipidemic patients [total cholesterol (TC) > 200 mg/dL, triglyceride (TG) > 150 mg/dL] and 75 healthy control subjects (TC < 200 mg/dL and  TG < 150 mg/dL) The PstI polymorphism was analyzed by PCR-RFLP.

Results: The frequencies of the PstI polymorphism minor allele (P2) were 22.14 and 14.7 in the case and control groups respectively (P>0.05). In the case group, patients with P2P2 genotype had lower serum HDL-c and apoAI, compared those with P1P1and P1P2 genotypes (P> 0.05).

Conclusion: Considerably, the presence of the rare P2 allele was not associated with lipid levels in the studied population. The association between the polymorphisms and dyslipidemia is quite complicated. We propose evaluation of PstI polymorphism with other polymorphic sites in the apoAI-CIII-AIV gene cluster

Keywords: Apolipoprotein A-I, Dyslipidemias, Genetic Polymorphism
Full-Text [PDF 581 kb]   (44 Downloads)    
Type of Study: Research | Subject: General
Received: 2016/11/22 | Accepted: 2017/04/23 | Published: 2017/06/21
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Pakdel A, Akbari eydgahi M R, Bandegi A R. Lack of association between PstI polymorphism in the 3' flanking region of the apolipoprotein AI gene and serum lipids levels in an Iranian population . koomesh. 2017; 19 (3) :619-625
URL: http://koomeshjournal.semums.ac.ir/article-1-3729-en.html
Volume 19, Number 3 ( Summer 2017, 19 (3). 505-711 2017) Back to browse issues page
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