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:: Volume 20, Issue 1 ( Winter 2017, 20 (1) 2018) ::
koomesh 2018, 20(1): 105-114 Back to browse issues page
Visual evoked potential frequency content: Effect of lysolecithin induced demyelination in rat optic chiasm
Zeinab Amirifalah , Manijhe Mokhtari-Dizaji * , Mohammad Javan
Abstract:   (875 Views)
Introduction: Visual evoked potential (VEP) is an effective tool in order to study the visual pathways. This study was performed to evaluate VEP frequency content and the effect of demyelination induction in optic chiasm in rats.
Materials and Methods: VEPs for 61 normal adult female Wistar rats (8-10 weeks) were recorded in the equal conditions and the component latencies of the mean VEPs were studied. Then, the VEP frequency content was evaluated in frequency space through Fast Fourier transforming. Meaningly, to evaluate the effect of the demyelination induction on VEP frequency content, two groups (n = 6 for each group) of rats were selected randomly and divided into the experimental and sham groups. The experimental group was injected lysolecithin into optic chiasm to induce demyelination. The sham group received saline injection into the optic chiasm. Correspondingly, VEP content compared between two groups before injection (day 0) and on days 3, 7, 14 and 21 post-lesion.
Results: The study of the VEP frequency content indicated delta and beta band power have the maximum (67.65±2.42) and minimum (4.36±0.5) percent in VEP frequency band powers, respectively. Moreover, the comparison between experimental and sham groups showed the decrease of beta band relative power on days 3 and 14 post-lesion in experimental group (p<0.05).
Conclusion: It seems that the VEP evaluation in frequency space can reveal the lysolecithin-induced demyelination effects before these effects are revealed in time space
Keywords: Visual Evoked Potential, Demyelinating Diseases, Optic Chiasm, Rats
Full-Text [PDF 731 kb]   (132 Downloads)    
Type of Study: Research | Subject: General
Received: 2016/11/3 | Accepted: 2017/10/28 | Published: 2018/01/1
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Amirifalah Z, Mokhtari-Dizaji M, Javan M. Visual evoked potential frequency content: Effect of lysolecithin induced demyelination in rat optic chiasm . koomesh. 2018; 20 (1) :105-114
URL: http://koomeshjournal.semums.ac.ir/article-1-3701-en.html


Volume 20, Issue 1 ( Winter 2017, 20 (1) 2018) Back to browse issues page
کومش Koomesh
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