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Protein-protein interaction network analysis of major depression disorder via proteomic approach from cerebrospinal fluid sample
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Majid Rezaei Tavirani   , Reza Vafaei , Vahid Mansouri , Mona Zamanian Azodi |
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Abstract: (4737 Views) |
| Introduction: As the major depression disorder (MDD) is one of the prevalent psychiatric conditions, molecular characteristic is important to gain a better understanding of its complex nature. In this study, the protein-protein interaction network analysis is carried out in order to have a better understanding the molecular mechanism of MDD.
Materials and Methods: The MDD differentially expressed proteins of cerebral fluid were extracted from the literature. Cytoscape Software was used for the network construction of 39 retrieved proteins. In addition, Cytoscape plug-ins, MCODE and ClueGO+CluePedia identified the protein complexes and biological processes, respectively.
Results: The MDD map centrality analysis identified 15 hub proteins. This network comprises of four protein complexes and seven significant biological processes.
Conclusion: In this study, some of the central proteins, protein complexes, and biological processes related to MDD are introduced. The further investigations can help validating possible drug targets and diagnostic biomarkers |
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| Keywords: Major Depression Disorder, Protein Interaction Maps, Protein Complex, Gene Ontology |
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Full-Text [PDF 685 kb]
(1133 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2016/07/16 | Accepted: 2017/01/23 | Published: 2017/06/21
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