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:: Volume 19, Issue 1 ( Winter 2017, 19 (1) 2017) ::
koomesh 2017, 19(1): 154-163 Back to browse issues page
Antinociceptive effects of aqeous extract Launaea acanthodes gum in mice
Hossein Nazari, Shayan Bidokhty, Abolfazl Mohammadi, Maryam Jafari, Abbas Ali Taherian
Abstract:   (2017 Views)

Introduction: Previous studies indicated that Launaea acanthodes (LA) can be effective against epilepsy, nervous disorder, local and articular pain and convulsion disorders. The aim of this study was to assessment the antinoceceptive effects of  LA on peripheral and visceral pain in mice by using hot plate (HP), tail flick (TF), formalin (FT) and writhing (WR) tests.

Materials and Methods: In this study 160 young adult male albino mice (25-30 g) were used (n = 8 in each group). Aqueous extract of LA gum (50, 100, and 200 mg/Kg IP) and saline (SAL) were injected 30 min before the pain evaluation tests. Acute and chronic pain was assessed by HP, TF and FT models and visceral pain was assessed by writhing test.

Results: Results indicated that LA has analgesic effects (P< 0.05) in comparison with the control and saline groups  and higher dose of LA was more effective (P< 0.001).

Conclusion: The above findings showed that LA have modulatory effects on acute, chronic and visceral pain

Keywords: Launaea acanthodes, Peripheral Pain, Visceral Pain, Mice
Full-Text [PDF 720 kb]   (384 Downloads)    
Type of Study: Research | Subject: General
Received: 2016/05/28 | Accepted: 2016/10/24 | Published: 2017/01/3
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Nazari H, Bidokhty S, Mohammadi A, Jafari M, Taherian A A. Antinociceptive effects of aqeous extract Launaea acanthodes gum in mice. koomesh. 2017; 19 (1) :154-163
URL: http://koomeshjournal.semums.ac.ir/article-1-3366-en.html


Volume 19, Issue 1 ( Winter 2017, 19 (1) 2017) Back to browse issues page
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