اکثر مکاتبات کومش از طریق ایمیل سایت می باشد.
لطفا Spam ایمیل خود را نیز چک نمایید.
   [Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 19, Issue 1 ( Winter 2017, 19 (1) 2017) ::
koomesh 2017, 19(1): 233-240 Back to browse issues page
Effects of dietary conjugated linoleic acid on oxidation markers and antioxidant defenses in rats with colorectal cancer
Nasrin Beheshti, Hosseein Davoodi, Zahra Kamal, Morteza Abdollahi, Marjan Ajami
Abstract:   (1887 Views)

Introduction: Colorectal cancer (CRC) is one of the most common types of cancer affecting 1.23 million individuals per year in the world. Recently, it is suggested that inflammation and oxidative stress play an importmat role in colorectal carcinogenesis. The aim of this syudy was to examine the effects of dietary conjugated linoleic acid (CLA) on oxidation markers and antioxidant defenses level in a rat model of colorectal cancer.

Materials and Methods: Sixteen male Wistar rats, weighing 250-300 g were divided into two groups: control and experimental. Both groups were injected subcutaneously, with 1,2- Dimethyl Hydrazine at a dose of 15 mg/kg of body weight, twice per week for 6 weeks. The control group and experimental groups were gavaged with water (2 ml/kg) and CLA (200 mg/kg), respectively, for the first 4 weeks of study. After 6 weeks, the rats were killed and their blood and colorectal tissues were collected.  The serum levels of superoxide dismutase (SOD), glutation peroxidase (GPx), paraxonase (PON) and myeloperoxidase (MPO) and also malondialdehyde (MAD) level in the colorectal tissue were measured.

Results: Findings indicated that MAD and MPO levels significantly decreased in the experimental group in comparison than the control group (P<0.001). SOD, GPx and PON significantly increased in the experimental group than the control group (P<0.001).

Conclusion: our findings suggest that CLA is a powerful substance which decreases oxidation markers, and increases antioxidant defenses in colorectal cancer

Keywords: Conjugated Linoleic Acid, Colorectal Cancer, Malondialdehyde, Antioxidants, Rats
Full-Text [PDF 585 kb]   (545 Downloads)    
Type of Study: Research | Subject: General
Received: 2016/02/1 | Accepted: 2016/07/23 | Published: 2017/01/3
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Beheshti N, Davoodi H, Kamal Z, Abdollahi M, Ajami M. Effects of dietary conjugated linoleic acid on oxidation markers and antioxidant defenses in rats with colorectal cancer. koomesh. 2017; 19 (1) :233-240
URL: http://koomeshjournal.semums.ac.ir/article-1-3218-en.html


Volume 19, Issue 1 ( Winter 2017, 19 (1) 2017) Back to browse issues page
کومش Koomesh
Persian site map - English site map - Created in 0.06 seconds with 32 queries by YEKTAWEB 4006