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:: Volume 19, Issue 1 ( Winter 2017, 19 (1) 2017) ::
koomesh 2017, 19(1): 84-92 Back to browse issues page
Effects of 10 weeks endurance exercise on mRNA expressions of angiogenesis factors of skeletal muscle following myocardial infarction in rats
Malihe Ardakanizade, Kamal Ranjbar, Farzad Nazem
Abstract:   (1816 Views)

Introduction: The effect of exercise training on skeletal muscle angiogenesis in myocardial infarction rats is not yet clear. Therefore, the aim of this study was to investigate the effect of exercise training on the gene expressions of angiogenesis factors in the soleus muscle following myocardial infarction (MI) in rats.

Material and Methods: Four weeks after the MI surgical procedures, 30 Wistar male rats were divided to the following groups: sham, MI-control and MI-exercise. The rats were subjected to aerobic training with moderate intensity for 10 weeks. After the last exercise-training session, soleus capillary density and the expression of angiogenic gene factors were measured by immunohistochemistry and RT-PCR, respectively.

Results: Capillary density and capillary to fiber ratio (C/F) significantly decreased 14 weeks after MI. Exercise training significantly increased capillary density and C/F ratio in soleus muscle. Furthermore, HIF-1 and TGF-β gene expression respectively increased and decreased, but, VEGF, FGF-2 and angiostatin gene expression did not changed in soleus muscle after training.

Conclusion: Results showed that MI significantly decreased soleus muscle capillary density. Furthermore, 10 weeks moderate endurance exercise ameliorate capillary density and C/F ratio, parallel to HIF-1 up regulation, TGF-β down regulation and unchanged VEGF, FGF-2 and angiostatin gene expression in soleus muscle after myocardial infarction.

Keywords: Myocardial Infarction, Angiogenesis Inducing Agents, Exercise, Exercise Therapy.
Full-Text [PDF 839 kb]   (572 Downloads)    
Type of Study: Research | Subject: General
Received: 2015/11/17 | Accepted: 2016/10/29 | Published: 2017/01/2
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ardakanizade M, ranjbar K, nazem F. Effects of 10 weeks endurance exercise on mRNA expressions of angiogenesis factors of skeletal muscle following myocardial infarction in rats. koomesh. 2017; 19 (1) :84-92
URL: http://koomeshjournal.semums.ac.ir/article-1-3117-en.html


Volume 19, Issue 1 ( Winter 2017, 19 (1) 2017) Back to browse issues page
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