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Factors that affecting survival of patients with acute myeloid leukemia
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Alireza Akbarzadeh Baghban   , Hossein Hosseinifard , Ahmad Reza Baghestani , Saharnaz Ahmadi , Mostafa Rezaei tavirani , Parviz Kokhaei |
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Abstract: (6997 Views) |
| Introduction: Acute myeloid leukemia (AML) is a heterogeneous clonal disorder of blood producing cells and it’s one of the most common malignant disorders in adults. The aim of this study was to evaluate the blood parameters and the results of the liver function tests, as an effective prognosis for survival in AML patients hospitalized in Taleghani hospital, Tehran.
Materials and Methods: In this cross-sectional study, patients (n=170) with AML diagnosis participated to study the laboratory results influencing their survival. Patients’ personal files were used as our source of data. Kaplan-Meier method and log-Rank tests were used for data analysis. Data modeling was performed using Cox regression model.
Results: The mean and median survival time of patients were 14.13 ± 0.93 and 12.23 months respectively. Fitted model showed that factors such as age at the time of diagnosis, WBC count, smoking, family history, LDH and AST levels were associated with chance of survival in patients with AML.
Conclusion: Our results showed that the age at the time of diagnosis, WBC count, smoking, family history, LDH and AST levels are effective factors on the chance of survival in AML patients. Therefore, considering these factors can increase the chance of survival in AML patients. |
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| Keywords: Acute Myeloid Leukemia, Survival Analysis, Liver function tests, blood parameters |
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Full-Text [PDF 522 kb]
(1483 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2015/10/1 | Accepted: 2016/02/10 | Published: 2016/03/15
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