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:: Volume 17, Issue 3 (بهار 1395: جلد 17. شماره 3 1395) ::
Koomesh 1395, 17(3): 701-706 Back to browse issues page
Nuclear magnetic resonance -based metabolomics analysis of patients exposed to sulfur mustard in different stages using random forest method
B. Fatemeh Nobakht M. Gh. , Rasoul Aliannejad , Afsaneh Arefi Oskouie , Fariba Fathi , Hossein Ali Safakhah , Mostafa Rezaei-Tavirani
Abstract:   (4934 Views)
Introduction: Metabolomics is a powerful technique for determination of biomarkers. Here, we aimed to determine discriminatory metabolomic profiles in different stages of sulfur mustard-exposed patients (SMEPs). Materials and methods: Nuclear magnetic resonance spectroscopy was used to analyze serum samples from 17 SMEPs (normal group patients) and 17 SMEPs (severe group patients). Multivariate statistical analysis using random forest (RF) was performed on a ‘training set’ (70% of the total sample) in order to produce a discriminatory model classifying two groups of patients, and the model tested in the remaining subjects. Results: A classification model was derived using data from the training set with an area under the receiver operating curve (AUC) of 0.87. In the test set (the remaining 30% of subjects), the AUC was 0.8, thus RF model had good predictive power. We observed significant changes in lipid, amino acids and energy metabolism between two groups of patients. Conclusion: Nuclear magnetic resonance spectroscopy of serum successfully differentiates two groups of patients exposed to sulfur mustard. This technique has the potential to provide novel diagnostics and identify novel pathophysiological mechanisms, biomarkers and therapeutic targets
Keywords: Mustard Gas, Serum, Metabolomics
Full-Text [PDF 719 kb]   (1235 Downloads)    
Type of Study: Research | Subject: General
Received: 2015/09/19 | Accepted: 2015/11/8 | Published: 2016/03/16
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Nobakht M. Gh. B F, Aliannejad R, Arefi Oskouie A, Fathi F, Safakhah H A, Rezaei-Tavirani M. Nuclear magnetic resonance -based metabolomics analysis of patients exposed to sulfur mustard in different stages using random forest method. Koomesh 1395; 17 (3) :701-706
URL: http://koomeshjournal.semums.ac.ir/article-1-3038-en.html


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Volume 17, Issue 3 (بهار 1395: جلد 17. شماره 3 1395) Back to browse issues page
کومش Koomesh
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