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Role of 5HT1A receptor on potentiation of field potentials in dentate gyrus of pentylenetetrazol -kindled rats
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Atefeh Kiani Nejad   , Gholamhassan Vaezi , Hassan Azhdari-Zarmehri , Mohammad Mohammad-Zadeh |
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Abstract: (5028 Views) |
| Introduction: There are many evidence to indicate the role of serotoninergic system and serotoninergic activation in seizure attacks. Given the role of serotonin 5-HT1A receptors in synaptic activity and seizure models, and, the similarity of the mechanisms involved in causing seizures and long term potentiation (LTP), the purpose of this study was to investigate the role of this receptor in pentylenetetrazol (PTZ)-induced synaptic strengthening.
Materials and Methods: 24 Male Wistar rats (n=20, 220-320 g) were divided into 6 groups Group1 (control) without any interference after surgery stereotoxic placement of stimulation electrode, Local Field Potential (LFP) was recorded for 20min .Then the LTP was induced with tetanic stimulation. Group2: All experimental procedures were similar to the group 1, the difference was that the one-month period before the surgery, the animals kindled with PTZ injection. Groups 3-5: All experimental procedures were similar to the group 2, the difference was that the serotonin receptor antagonist (WAY-100635 at a concentration 12.5, 25 and 50nM) was injected intraventricularly. Group 6 received WAY-100635 only.
Results: The results showed that groups 1 and 2 were different responded from one another after LTP induction of LTP with tetanic pulse (p |
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| Keywords: Epilepsy, Kindling, Serotonin 5HT1A Receptor Antagonist, Electric Stimulation, Rats |
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Full-Text [PDF 592 kb]
(1168 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2015/09/10 | Accepted: 2016/12/19 | Published: 2017/06/21
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