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The effects of vasopressin on amnesia-induced by electroconvulsive shock in rats
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M. حاج زاده   , H. میلادی گرجی , E. جلالی , H. اسماعیلی |
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Abstract: (14805 Views) |
| Introduction: Vasopressin as a neu rotransmitter can improve the memory disorders due to
ECS, brain trauma, diabetes insipidus, Alzheimer's disease and senile dementia. In the presen t
experiment the effects of desmopressin were studied on amnesia due To elect roconvulsive shock
(ECS) in rats.
Materials and Methods: Forty male Wistar albino rat s, aged 3-4 months with 190 -260 gr
body weight were studied in complex T maze or Morris water maze (MWM). After a primary
introduction to T maze (four day), Twenty rats with a 16 hr period of thirsty introduced to the
maze, which they have to find a botte! of water to drink. In MWM twenty rats were treated for
ten days in training trials, spatial exploration and workin g memory trials, they have to swim in
water to find the hidden platform where can rest. Then each rat in test gro up recived 10 fLgikg
B.W of desmopressin and each rat in contro l group recived the same volume of 0.9% salin by ip
injection Ten min perior to ECS. Ten min after injection each rat was treated with ECS and 10
min after that rat was put in T-maze and / or water maze.
Results: For both test and control groups the average time to reach the goal in T and water
maze and the unmber of errors in T maze was not st atistically -different on the day before
experiment. On the other hand, on the day of experiment by T maze the average of the time to
find the goal for test group was 9±4.78 sec and for control group was 15.25±5.67 sec and the
difference are statistically significan t (P =0.032 ). With water maze the difference between the
time to find the platform in the day befor and on the day of experiment in test group was -0.489
sec and in control was + 5.07 sec which is statistically significant ( p=0.047).
Conclusion: It may be concluded that desmopressin can facilitat e retrieval and consolidation
of spatial memory and improve the retrograde and anterograde amnesia due to ECS |
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| Keywords: Vasopressin, Desmopressin, Amnesia, Learning, Memory, ECS, T maze, MWM |
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Full-Text [PDF 1379 kb]
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Type of Study: Research |
Subject:
General
Received: 2008/12/22 | Published: 2003/02/15
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