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:: Volume 16, Issue 2 (زمستان 1393: 16 (2) 1393) ::
Koomesh 1393, 16(2): 202-206 Back to browse issues page
Therapeutic effects of fludarabine-cyclophosphamide combined therapy in Iranian patients with B-cell chronic lymphocytic leukemia
Kamran Moshfeghi , Ghasem Mosayebi
Abstract:   (5162 Views)
 Introduction: The aim of this study was to investigate the efficacy of fludarabine-cyclophosphamide combination in treatment of Iranian patients with B-cell chronic lymphocytic leukemia (B-CLL). Materials and Methods: Between April 2011 and July 2013, 20 patients with B-CLL (median age 63 years) received a regimen that consisted of fludarabine 25 mg/m2 and cyclophosphamide 250 mg/m2, days 1-3, orally, every 4 weeks, for a maximum of 6 courses. Clinical appearances and percentage of CD5+/CD19+ cells as minimal residual disease detected by flow cytometry before and 6 months after treatment. Results: The frequency of CD5+, CD5+/CD19+ and CD19+-cells were significantly high (70-90 %) in the peripheral blood of all the patients, before treatment. The percentage of CD2 and CD3+-cells were significantly increased after treatment (p
Keywords: Leukemia, Lymphocytic, Chronic, B-Cell, Cyclophosphamide, Flow cytometry
Full-Text [PDF 450 kb]   (1470 Downloads)    
Type of Study: Research | Subject: General
Received: 2014/02/1 | Accepted: 2014/07/9 | Published: 2014/12/16
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Moshfeghi K, Mosayebi G. Therapeutic effects of fludarabine-cyclophosphamide combined therapy in Iranian patients with B-cell chronic lymphocytic leukemia. Koomesh 1393; 16 (2) :202-206
URL: http://koomeshjournal.semums.ac.ir/article-1-2394-en.html


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Volume 16, Issue 2 (زمستان 1393: 16 (2) 1393) Back to browse issues page
کومش Koomesh
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