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Effects of hydroalcholic and chloroformic extracts of Salvia Candidissima on hyperalgesia and edema during adjuvant-induced arthritis
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A. li Mohamad khani zadeh   , Jalal Zaringhalam moghadam , A. li Sonboli , Mahdi Ayari , Somayeh Mirjafari |
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Abstract: (5489 Views) |
| Introduction: Inflammatory sympotoms such as edema and
hyperalgesia were induced by some mediators like cytokines in response to
irritant stimulus. The aim of this study was to investigate the effects of
hydroalcholic and chloroformic extracts of Salvia Candidissima on hyperalgesia
and edema during adjuvant-induced arthritis in rats. Materials and Methods: Inflammation was induced by ingle sabcutaneous injection of
CFA to rat hindpaw. Hydroalcholic and chloroformic extracts of Salvia
Candidissima prepared from aerial part of plant and different dose of extracts
(25, 50 and 100/kg) were administrated (i.p.) during the 7-day study.
Indomethacin (5 mg/kg) used as positive control. Hyperalgesia and edema were
assessed at 0, 3 and 7 days after artrithit induction by CFA by radiant heat
and plethysomometer, respectively. Results: The
result showed that hydroalcholic and chloroformic extacts of Salvia
Candidissima at dose of 50 mg/kg caused significant reduction in hyperalgesia
and edema on days 3 and 7 as compared
with the day zero, negative control and
positive control (receiving indomethacin at dose of 5 mg/kg, daily) groups
(p |
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| Keywords: Plant extract, Salvia Candidissima, Hyperalgesia, Edema |
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Full-Text [PDF 813 kb]
(2108 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2013/12/1 | Accepted: 2014/06/11 | Published: 2014/12/14
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