Introduction: Diabetes is the most common endocrine disease, which in many biochemical
parameters such as glucose and lipid profiles changes. Propolis is as a
bee-collected natural product is very useful and has diverse biological
properties. The propose of this study was to test the effects of
hydro-alcoholic extracts of Iranian Propolis on serum glucose, lipids profile,
BUN and creatinine levels in streptozotocin-induced diabetic Rats.
Materials and Methods: This study was performed on 40 male wistar rats that ther were divided
into 5 groups: control, diabetic, diabetic vehicle, and two groups of Propolis-treated
diabetic. Diabetes was induced in the rats by single dose injection of
streptozotocin (STZ, i.p., 60 mg/kg bwt). The hydro-alcoholic extracts of
Propolis was administered gavages at doses of 100 and 200 mg/kg after diabetes
induction for 6 weeks. At the end of administration period, the body weight,
kidney weight, levels of lipid profile (LDL, HDL, TG and cholesterol), blood
urea nitrogen (BUN), creatinine and glucose were measured.
Results: Administration of the hydro-alcoholic extracts of Iranian Propolis
significantly increased body weight and reduction kidney weight in treated
diabetic rats. In addtion, Propolis significantly inhibited the increasing of
glucose, BUN, creatinine, total cholesterol, triglyceride and LDL-c levels and
increased HDL-c levels in Propolis-treated diabetic rats as compared untreated
diabetics (P<0.05).
Conclusion: The results indicate that
hydro-alcoholic extracts of Iranian Propolis can control blood glucose and
modulate some of biochemical factors in diabetic rats
Sameni H, Ramhormozi P, Bandegi A, Taherian A, Safari M, Tabriziamjad M. Effects of hydroalcoholic extract of Iranian Propolis on blood serum biochemical factors in streptozotocin-induced diabetic rats. koomesh. 2014; 15 (3) :388-395 URL: http://koomeshjournal.semums.ac.ir/article-1-2096-en.html