[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 15, Issue 3 (Spring 2014, 15 (3). 275-404 2014) ::
koomesh 2014, 15(3): 388-395 Back to browse issues page
Effects of hydroalcoholic extract of Iranian Propolis on blood serum biochemical factors in streptozotocin-induced diabetic rats
Hamidreza Sameni * , Parisa Ramhormozi , Ahmadreza Bandegi , Abbasali Taherian , Manochehr Safari , Mohmmadhasan Tabriziamjad
Abstract:   (7317 Views)
 

Introduction: Diabetes is the most common endocrine disease, which in many biochemical parameters such as glucose and lipid profiles changes. Propolis is as a bee-collected natural product is very useful and has diverse biological properties. The propose of this study was to test the effects of hydro-alcoholic extracts of Iranian Propolis on serum glucose, lipids profile, BUN and creatinine levels in streptozotocin-induced diabetic Rats.

 

Materials and Methods: This study was performed on 40 male wistar rats that ther were divided into 5 groups: control, diabetic, diabetic vehicle, and two groups of Propolis-treated diabetic. Diabetes was induced in the rats by single dose injection of streptozotocin (STZ, i.p., 60 mg/kg bwt). The hydro-alcoholic extracts of Propolis was administered gavages at doses of 100 and 200 mg/kg after diabetes induction for 6 weeks. At the end of administration period, the body weight, kidney weight, levels of lipid profile (LDL, HDL, TG and cholesterol), blood urea nitrogen (BUN), creatinine and glucose were measured.

 

Results: Administration of the hydro-alcoholic extracts of Iranian Propolis significantly increased body weight and reduction kidney weight in treated diabetic rats. In addtion, Propolis significantly inhibited the increasing of glucose, BUN, creatinine, total cholesterol, triglyceride and LDL-c levels and increased HDL-c levels in Propolis-treated diabetic rats as compared untreated diabetics (P<0.05).

 Conclusion: The results indicate that hydro-alcoholic extracts of Iranian Propolis can control blood glucose and modulate some of biochemical factors in diabetic rats
Keywords: Diabetes, Propolis, Streptozotocin, Blood glucose, Lipid profile
Full-Text [PDF 252 kb]   (1280 Downloads)    
Type of Study: Research | Subject: General
Received: 2013/05/29 | Accepted: 2013/11/19 | Published: 2014/03/11
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA code


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Sameni H, Ramhormozi P, Bandegi A, Taherian A, Safari M, Tabriziamjad M. Effects of hydroalcoholic extract of Iranian Propolis on blood serum biochemical factors in streptozotocin-induced diabetic rats. koomesh. 2014; 15 (3) :388-395
URL: http://koomeshjournal.semums.ac.ir/article-1-2096-en.html


Volume 15, Issue 3 (Spring 2014, 15 (3). 275-404 2014) Back to browse issues page
کومش Koomesh
Persian site map - English site map - Created in 0.05 seconds with 31 queries by YEKTAWEB 3764