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The teratogenic effects of copper chloride (II) on the cervical spinal development of mouse embryos
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S. پروری   , M. مهدیزاده , K. پریور , M. نوبخت |
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Abstract: (12750 Views) |
| Introduction: Copper is an essential trace element. This element is absorbed in digestive system. Copper chloride is one of the most important of its components. The lack of copper results to structural and metabolic defects. According to recent studies, copper has toxic effect on central nervous system. In spite of that, a little amount of copper is necessary for brain development, but high amounts of it may cause defects in central nervous system.
Materials & Methods: Eighteen pregnant mice were divided in intact, control and experimental groups. Each group had six pregnant mice. Experimental group was received CuCl2 (5 mg/kg. I.P) on 7th, 8th and 9th gestational days. Control group was injected with distilled water on the same days. Intact group was received no injection. Embryos were extruded from the uterus on 15th gestational day. Weight and number of absorbed embryos were measured. Following tissue passage and sectioning, sections were stained with H&E.
Results: According to macroscopic measurement, weight of embryos in all experimental groups was decreased significantly (P |
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| Keywords: Copper chloride, Cervical spinal cord, Development, Cell death, Mouse |
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Full-Text [PDF 364 kb]
(2751 Downloads)
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Type of Study: Applicable |
Subject:
General
Received: 2008/09/16 | Published: 2003/08/15
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