Introduction: Serum amyloid A (SAA) is an acute-phase protein, which is a clinically
useful marker of inflammation and associates strongly with increased risk of
cardiovascular events. The purpose of this study was to investigate the effect
of resistance training with progressive load on serum levels of SAA and
apolipoprotein A-I (apoA-I) in streptozotocin-induced diabetic rats. Materials and Methods: Twenty four male Wister rats (292 ± 20g) were randomly divided into three
groups: non-diabetic control, diabetic control, and diabetic training. The rats
in diabetic training group were subjected to a resistance training program (3
days/wk, for 4 wk) consisted of climbing a ladder carrying a load suspended
from the tail. Following four weeks resistance training serum lipid profile,
glucose, SAA and apoA-I concentrations were measured. Results: We did not find any significant difference in serum lipid profile between
all groups. Serum levels of SAA and apoA-I were significantly higher in both
diabetic groups compare with non-diabetic control group (respectively, P=0.020
& P= 0.001). After 4 weeks of resistance training serum apoA-I levels
significantly increased compared with diabetic control group (P= 0.035), but we
did not find any significant difference in SAA levels between diabetic groups. Conclusion: This study indicated that
resistance training could increase serum apoA-I levels in diabetic rats without
significant changes in lipid profile and SAA levels. These changes may mitigate
the risk for atherosclerosis progression and its clinical consequences in
diabetic conditions
safarzade A, Rohi H, Fathi R, Talebi-Garakani E. Effect of progressive resistance training on serum amyloid A and apolipoprotein A-I levels in diabetic Rats. Koomesh 1392; 15 (1) :22-30 URL: http://koomeshjournal.semums.ac.ir/article-1-2031-en.html