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Role of orexinergic system in the effects of morphine on food and water intake in male rat
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Mohammad Sofiabadi   , Samad Nazemi , Elaheh Erami , Hassan Azhdari-Zarmehri |
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Abstract: (7685 Views) |
| Introduction: Hypothalamic orexinergic neurons playan important role in food consumption
and expresses µ-opioid receptor. This study was investigated the interaction of
orexinergic system on effects of morphine on food and water intake in male rats. Materials and Methods: 40 male Wistar rats (250–300 g) were used in this study. The animals were
operated stereotaxic and then after a week recovery period were divided into
the following groups: 1. control 2.vehicle injection 3. morphine 4. orexin
receptor 1 antagonist 5. orexin receptor 1 antagonist + morphine group. Drugs
were injected into lateral ventricle (LV) after 12 hours food deprivation and
then, the feeding and drinking behaviors were calculated 4h after injection. Results: The injection of morphine into LV increased the amount of food intake and numbers
of referral to feeding plate. Administration of orexin receptor1 antagonist
(SB334867) attenuated significantly morphine-induced feeding, but had no effect
on morphine induced water consumption. Morphine decreased water intake but
increased numbers of referral for water bottle, which this effect was
significantly attenuated by administration of SB334867. Conclusion: It may be orexin is at least one of the pathways of opiates effects on
food and water intake. |
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| Keywords: Orexin receptor, Morphine, Drinking, Eating, Rat |
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Full-Text [PDF 276 kb]
(1645 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2013/02/24 | Accepted: 2013/11/26 | Published: 2014/03/11
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