Introduction: Several
reports indicated the role of angiotensin II antagonists in suppression of
different tumvors. Some of the recent studies point to the increasing effect of
angiotensin II on expression of important factors regarding to the tumor
growth. Also the role of integrins in growth and metastasis of tumoral cells is
very important but the role of angiotensin II in the expression of integrins is
not clear yet. Materials
and Methods: Melanoma tumors
were induced in C57 mice using S.C. injections of B16-F10 cells. Losartan was
I.P. injected to C57 mice. Also B16-F10 cells
were cultured and incubated with angiotensin II with or without losartan for
two hours and the expression of α3, αv and b3 integrins were
studied using western blotting. Results: Our
results indicate the suppressing role of losartan on tumor growth (day17, P=0.013
day18: P=0.0015). In addition angiotensin II increased significantly the
expression of studied integrins in B16-F10 cultured cells (integrin αV: P=0.049
Integrin α3: P= 0.016 integrin β3: P=
0.037), and losartan completely abolished this effect. Conclusion: The role of angiotensin II in tumor growth may be because of reasons
including its role in elevating the expression levels of α3, αv and 3
integrins. In animal model of melanoma, losartan suppressed the tumor growth
through AT1 receptors inhibition. The present study indicates the importance of
the drugs such as losartan besides the standard therapeutic approach for tumors
Esfandiary Yeganeh N, Galustanian N, Nasirzadeh Goljahi A, Ghodrati M, Boghozian R, Rasouli E, et al . Effects of angiotensin II on expression of α3, αv and 3 integrin proteins in B16-F10 melanoma cells. Koomesh 1392; 14 (4) :396-403 URL: http://koomeshjournal.semums.ac.ir/article-1-1983-en.html