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Study of XmnI polymorphism in 5´ region of the apoAI gene in Iranian hyperlipidemic subjects
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A. R. بندگی   , M. فیروز رأی , A. احسانیزنوز , M. R. اکبریعیدگاهی , A. A. شعبانی , M. ملک |
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Abstract: (13094 Views) |
| Introduction: Several studies have demonstrated the relationship between polymorphisms in the ApoAI – CIII – AIV gene cluster and hyperlipidemia. This study was conducted to elucidate the association between polymorphism of ApoAI/XmnI and Iranian hyperlipidemic subjects.
Materials and Methods: Total genomic DNA was prepared from seventy-six Iranian patient with primary hyperlipidemia and seventy-five normolipidemic subjects. The subjects in the control group were age- and sex-matched to the patients. Fragment of 392 bp for 5´ region of the apoAI gene (C-2500T) was amplified by polymerase chain reaction (PCR).
Results: In the hyperlipidemic group, the genotype frequency of X1X1, X1X2, X2X2 were 0.63, 0.24, 0.13, respectively. In the control group those were 0.81, 0.11 and 0.08, respectivley. There was a significant difference (p |
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| Keywords: Polymorphism, XmnI, Hyperlipidemia, Apolipoprotein AI |
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Full-Text [PDF 256 kb]
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Type of Study: Applicable |
Subject:
General
Received: 2008/09/14 | Published: 2004/11/15
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