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:: Volume 13, Issue 3 (Spring 2012 13(3) 279- 396 2012) ::
koomesh 2012, 13(3): 368-375 Back to browse issues page
Effects of of 3,4-methylendioxymethamphetamine (ecstasy) on rat liver structure
Azam Bagheri Haghighi , Esmail Fattahi * , Mohsen Forozanfar , Vahid Hemayatkhah Jahromi
Abstract:   (12314 Views)

  Introduction: Ecstasy (methylendioxymethamphetamine) is a stimulant drug that has various side effects on nerve system, cardiovascular and immune system. This substance affects body tissues and can cause their death. Therefore, in the present study, we investigated the effects of ecstasy on liver tissues in Wistar rats.

  Materials and Methods: Fifty Wistar rats, ranging 5-6 weeks of age, were divided into five groups (n=10) including control, sham, experimental 1, 2 and 3. In the experimental groups, the animals were injected with the consecutive doses of ecstasy (2, 4 and 8 mg/kg, I.P, for two weeks). The sham group received normal saline and the control group had no injection. Animals were sacrificed 12 hours after the latest injection of ecstasy. Liver tissues sections were provided and stained by hematoxylin-eosin to investigate the histopathological changes.

  Results: Hepatocytes cells significantly decreased in experiment groups as compared with the control and sham groups (p<0.05). This decrease was more severe with higher doses. The results showed that numbers of kuppfer cells and liver weight were increased and the degree of changes depended on the dose.

Conclusion: According to the results, ecstasy might cause damages on liver tissue in higher and consecutive doses. So, this study suggests more attention on using of these kinds of drugs
Keywords: Rats, 3, 4 methylenedioxyamphetamine (Ecstasy), Hepatocyt, Liver.
Full-Text [PDF 690 kb]   (1508 Downloads)    
Type of Study: Research | Subject: General
Received: 2011/04/18 | Accepted: 2011/10/30
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Bagheri Haghighi A, Fattahi E, Forozanfar M, Hemayatkhah Jahromi V. Effects of of 3,4-methylendioxymethamphetamine (ecstasy) on rat liver structure . koomesh. 2012; 13 (3) :368-375
URL: http://koomeshjournal.semums.ac.ir/article-1-1285-en.html

Volume 13, Issue 3 (Spring 2012 13(3) 279- 396 2012) Back to browse issues page
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