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:: Volume 12, Issue 3 (Spring 2011) ::
koomesh 2011, 12(3): 305-3313 Back to browse issues page
Anti-hyperalgesic and anti-inflammatory effects of Achillea santolina and Stachys athorecalyx extracts on complete Freund's adjuvant–induced short-term inflammation in male wistar rats
Elaheh Tekieh , Akhtar Akbari , Homa Manaheji , Shamsali Rezazadeh , Jalal Zaringhalam *
Abstract:   (12765 Views)

  Introduction: Immune system is involved in the etiology and path physiologic mechanisms of inflammation. Medicinal plants are an important source of substances which are claimed to induce non-specific immune modulator effects. Given the above information and the role of IL-6 in inflammation and pain induction, this study investigated the effects of Achillea santolina and Stachys athorecalyx methanolic and defatted extracts on cmplete Freund's adjuvant (CFA) -induced short term inflammation in male Wistar rats

  Materials and Methods: Inflammation was induced on day zero by CFA injection in hind paw of rats. Methanolic and defatted extractions were prepared form aerial parts of both plants. 50, 100 and 200 mg/kg doses of extracts were selected for IP treatment during 6 days after CFA injection.

  Results: Results indicated dose related effects of A. santolina and S. athorecalyx extracts on edema, hyperalgesia and serum IL-6 level during inflammation. Although, both methanolic and defatted extracts of S. athorecalyx showed a significant reduction in the inflammatory symptoms, no significant differences was observed between these two kinds of extracts of S.athorecalyx with respect to their anti inflammatory effects. Only methanolic extract of A. santolina was effective during CFA-induced inflammation.

  Conclusion: These results could suggest that short-term administration of A. santolina and S. athorecalyx extracts possess potent anti-inflammatory effects and modulate paw edema, hyperalgesia and serum IL-6 level during CFA–induced inflammation. In addition, these dose-dependent effects may mediate via different extract supplements which need more investigations.

  

Keywords: Hyperalgesia, Inflammation, Stachys athorecalyx, Achillea santolina, Rat
Full-Text [PDF 269 kb]   (2069 Downloads)    
Type of Study: Research | Subject: General
Received: 2011/03/1
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Tekieh E, Akbari A, Manaheji H, Rezazadeh S, Zaringhalam J. Anti-hyperalgesic and anti-inflammatory effects of Achillea santolina and Stachys athorecalyx extracts on complete Freund's adjuvant–induced short-term inflammation in male wistar rats. koomesh. 2011; 12 (3) :305-3313
URL: http://koomeshjournal.semums.ac.ir/article-1-1242-en.html


Volume 12, Issue 3 (Spring 2011) Back to browse issues page
کومش Koomesh
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