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:: Volume 12, Issue 3 ((پياپی 39)، بهار 1390) ::
Koomesh 1390, 12(3): 259-265 Back to browse issues page
Determination of serum paraoxonase phenotype distribution by double-substrate method in patients with coronary artery disease
Abdolkarim مهروز , Mohammad نوری , Mohammad-Reza رشیدی , Naser اصلان‌آبادی , Durdi قوجق
Abstract:   (13678 Views)
  Introduction: Considering the high incidence of patients with coronary artery disease (CAD) in the Iranian population and a preventive role of serum paraoxonase (PON1) in development of CAD, the present study was designed to determine the distribution of PON1 phenotypes in patients with CAD.   Materials and Methods: A total of 61 patients with coronary stenosis of 70% were included in this study. Paraoxonase and arylesterase activities were measured using paraoxon and phenylacetate as substrate, respectively. Phenotyping of the PON1 Q192R polymorphism was determined by calculating the ratio of salt-stimulated paraoxonase activity to arylesterase activity (double-substrate method).   Results: Patients with stenosis of 70% at ratios of 2.42 and 5.91. In patients with stenosis of 70% were 48%, 41% and 11%, respectively.   Conclusions: Based on his study and other studies conducted in Iran, it can be concluded that in the Iranian population there is no statistically difference in phenotype distribution of PON1 between patients with CAD (with severe stenosis or mild stenosis) and healthy individuals.  
Keywords: Phenotype distribution, Serum paraoxonase, Arylesterase, Coronary stenosis
Full-Text [PDF 242 kb]   (2201 Downloads)    
Type of Study: Research | Subject: General
Received: 2011/02/23 | Published: 2011/04/15
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مهروز A, نوری M, رشیدی M, اصلان‌آبادی N, قوجق D. Determination of serum paraoxonase phenotype distribution by double-substrate method in patients with coronary artery disease . Koomesh 1390; 12 (3) :259-265
URL: http://koomeshjournal.semums.ac.ir/article-1-1228-en.html


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Volume 12, Issue 3 ((پياپی 39)، بهار 1390) Back to browse issues page
کومش Koomesh
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