Exosomes are lipid bilayer-enclosed nano-sized vesicles, which carry various biomolecules including proteins, lipids, and microRNAs. SARS-CoV-2-loaded exosomes can be entered into the susceptible host cells, and transported viral components which are associated with viral particles intercellular transmission and spread of infection. Over-stimulation of the immune system followed by excessive proinflammatory cytokine production is a hallmark of COVID-19. Mesenchymal stem cell-derived exosomes are a potential therapeutic option in COVID-19 due to their ability to decrease cytokine storm, improve tissue regeneration, and prevent multi-organs failure. Unraveling the exact role of exosomes underlying COVID-19 infection will be beneficial in understanding novel aspects of COVID-19 pathogenesis and therapy. This study aimed to investigate the importance of exosomes in COVID-19
Basiri P, Soheilifar M H, Nobari S, Nikfarjam A H, Keshmiri Neghab H, Afshar S, et al . Significance of exosomes in COVID-19 pathogenesis and therapy. Koomesh 1400; 23 (6) :673-682 URL: http://koomeshjournal.semums.ac.ir/article-1-6841-en.html