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:: Volume 19, Issue 4 (Autumn 2017, 19 (4): 2017) ::
koomesh 2017, 19(4): 735-741 Back to browse issues page
Investigation of blood levels of vitamin D in women with breast cancer and its correlation with prognostic markers
Vahid Semnani , Ensieh Farhidzadeh , Majid Mirmohammadkhani , Farahnaz Ghahremanfard *
Abstract:   (886 Views)
Introduction: Breast cancer is the most common cancer among women and the second cause of death after lung cancer. Several studies have been conducted to find the better prognosis in patients with breast cancer, which have associated with contradictory results. Current study was done in order to find the relationship between vitamin D and tumor markers and to improve the prognosis of breast cancer patients
Materials and Methods: In this cross-sectional descriptive-analytic study, 105 patients referred to oncology clinics of Fatemieh and Kowsar hospitals in Semnan city (Iran) from 2012 to 2016 years were evaluated.  Levels of vitamin D, prognostic markers of breast cancer including estrogen, progesterone, HER-2, P53 and Cyclin D1 receptors and menopause status of patients and also relationship between them were assessed.
Results: The results showed that mean of vitamin D was optimal (22.8±9.48) and the maximum frequency of markers related to ER and PR and the minimum one related to HER2. There was not statistically significant relationships between markers and level of vitamin D, but menopausal status and the level of vitamin D had a significant relationship, so that the level of vitamin D in menopausal women was higher than non-menopausal women (p<0.05). Also, association between the status of tumor markers and menopausal status was not found.
Conclusion: The level of vitamin D in women with breast cancer was in an adequate level and the level of this vitamin was not associated with prognostic markers. Further studies are suggested in this regard
Keywords: Breast Cancer, Tumor Marker, Vitamin D, Menopause.
Full-Text [PDF 570 kb]   (212 Downloads)    
Type of Study: Research | Subject: General
Received: 2016/10/24 | Accepted: 2017/08/9 | Published: 2017/10/2
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Semnani V, Farhidzadeh E, Mirmohammadkhani M, Ghahremanfard F. Investigation of blood levels of vitamin D in women with breast cancer and its correlation with prognostic markers . koomesh. 2017; 19 (4) :735-741
URL: http://koomeshjournal.semums.ac.ir/article-1-3686-en.html


Volume 19, Issue 4 (Autumn 2017, 19 (4): 2017) Back to browse issues page
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