[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 6, Issue 1 (11-2004) ::
koomesh 2004, 6(1): 49-56 Back to browse issues page
Role of saphenous nerve in the behavioral responses of neuropathic pain – due to chronic constriction injury in rats
H.A. Safakhah * , H. Manaheji
Abstract:   (11889 Views)
Introduction: The chronic constriction injury (CCI) was introduced by Bennett and Xie in 1988 as an animal model of peripheral mononeuropathy. In this model, serious sensitivity to the thermal and mechanical allodynia and hyperalgesia is increased the areas in which sciatic nerve innervated. The spread of receptive fields of the saphenous nerve which innervates the medial part of the foot. In this study, we have examined the behavioral effects of the section of saphenous nerve at the time of applying CCI. Material and Methods: Adult male Sprague – Dawley strain, with the weight 200 – 300 grs, used for experiments. Animals divided into four groups: sham operated, CCI group, cut of saphenous nerve (saph.) and CCI + saph. Two weeks after post operation, animals tested for behavioral responses: thermal allodynia (acetone blob and immersion of hind paw in 10°C water) thermal hyperalgesia (immersion of hind paw in 42°C water) mechanical allodynia (Von Frey), mechanical hyperalgesia (Pin Prick) and usage of damage paw. Results: All symptoms of the neuropathic pains were appeared among all animals which went under CCI. CCI + Saph group showed analgesia, thermal allodynia and hyperalgesia, mechanical hyperalgesia and also usage of damage paw, except in mechanical allodynia. Conclusion: Results indicated that saphenous nerve may affect on behavioral responses of neuropathic pain related CCI. Saphenous nerve (as a neighboring with sciatic nerve) may affecte on behavioral responses of neuropathic pain, probably by making collateral branches which may penetrate into the damage area.
Keywords: Neuropathic pain, CCI, Sciatic nerve, Saphenous nerve
Full-Text [PDF 194 kb]   (1657 Downloads)    
Type of Study: Applicable | Subject: General
Received: 2008/09/14 | Accepted: 2018/01/17 | Published: 2018/01/17
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA code


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Safakhah H, Manaheji H. Role of saphenous nerve in the behavioral responses of neuropathic pain – due to chronic constriction injury in rats. koomesh. 2004; 6 (1) :49-56
URL: http://koomeshjournal.semums.ac.ir/article-1-165-en.html


Volume 6, Issue 1 (11-2004) Back to browse issues page
کومش Koomesh
Persian site map - English site map - Created in 0.07 seconds with 30 queries by YEKTAWEB 3731