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The effect of long-term oral administration of Nigella. sativum on the contractile reactivity of thoracic aorta in diabetic rats
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M. روغنی   , T. بلوچنژاد مجرد , M. R. واعظمهدوی , M. واسعی |
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Abstract: (14826 Views) |
| Introduction: Therapeutics, especially medical plants with minimum side-effects are of high value in preventing vascular complications of diabetes mellitus in long term. Considering the evidences about the anti-diabetic effects of Nigella. Sativum (NS), the current study was conducted to evaluate the effect of oral two-month administration of NS on the contractile reactivity of isolated aorta in male diabetic rats.
Material & Methods: Male Wistar rats (n=32) were randomly divided into control, NS-treated control, diabetic, and NS-treated diabetic groups. For induction of diabetes, streptozotcin (STZ) was intraperitoneally administered. The treatment groups were received oral administration of NS-mixed pelleted food (6.25%) for two months. After two months, the contractile reactivity of aortic rings to KCl and noreadrenaline was determined using isolated tissue setup.
Results: Contractile response to cumulative KCl and noreadrenaline followed a dose-dependent pattern in aortic rings in all groups. In addition, the maximum contractile reactivity was significantly higher in the diabetic group compared to the control one (p |
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| Keywords: Nigella sativum, Vascular System, Diabetes Mellitus, Contractile Response, Rat |
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Full-Text [PDF 200 kb]
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Type of Study: Applicable |
Subject:
General
Received: 2008/09/6 | Published: 2006/08/15
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