اکثر مکاتبات کومش از طریق ایمیل سایت می باشد.
لطفا Spam ایمیل خود را نیز چک نمایید.
   [Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 23, Issue 5 (September and October 2021) ::
Koomesh 2021, 23(5): 582-590 Back to browse issues page
Effects of ellagic acid supplementation on glycemic index and insulin resistance in type 2 diabetics: A double blind randomized clinical trial
Mahnaz Ghadimi Yari , Farshad Foroughi , Sima Hashemipour , Mohamadreza Rashidi Nooshabadi , Mohammad Hossein Ahmadi , Bahman Ahadi Nezhad , Hossein Khadem Haghighian
Abstract:   (235 Views)
Introduction: The beneficial effects of polyphenols to improve glycemic status in patients with type 2 diabetes have been reported in scientific studies. The aim of this study was to investigate the effect of oral ellagic acid (EA) supplement on glycemic index and insulin resistance in type 2 diabetic patients.
Materials and Methods: In this double blind randomized clinical trial, 44 diabetic patients were selected, and were randomly assigned to the intervention group (22 subjects) and placebo (22 subjects) and received a capsule containing 180 mg of EA per day or placebo for 8 weeks, respectively. At the beginning and end of the study, demographic information, anthropometric indices, food intake and physical activity, biochemical factors of fasting and two-hour blood sugar, plasma insulin level, glycosylated hemoglobin percentage (HbA1c) and insulin resistance (IR) were measured.
Results: At the beginning and end of the study, there was no significant difference between the two groups in terms of anthropometric indices, food intake and physical activity (P>0.05). At the end of the study, receiving EA in the intervention group significantly reduced fasting and two-hour blood sugar means, plasma insulin levels, HbA1c percentage, and IR levels compared with placebo group (P<0.05).
Conclusion: EA supplementation can be helpful as a dietary antioxidant supplement in patients with type 2 diabetes by improving chronic side effects. This may be due to the antioxidant power of this polyphenol.
Keywords: Ellagic Acid, Glycemic Index, Insulin Resistance, Type 2 Diabetes Mellitus
Full-Text [PDF 1173 kb]   (63 Downloads)    
Type of Study: Research | Subject: General
Received: 2020/04/19 | Accepted: 2021/04/28 | Published: 2021/09/28
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA

Ethics code: IR.QUMS.REC.1398.079
Clinical trials code: IRCT20141025019669N13


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ghadimi Yari M, Foroughi F, Hashemipour S, Rashidi Nooshabadi M, Ahmadi M H, Ahadi Nezhad B et al . Effects of ellagic acid supplementation on glycemic index and insulin resistance in type 2 diabetics: A double blind randomized clinical trial. Koomesh. 2021; 23 (5) :582-590
URL: http://koomeshjournal.semums.ac.ir/article-1-6336-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 23, Issue 5 (September and October 2021) Back to browse issues page
کومش Koomesh
Persian site map - English site map - Created in 0.04 seconds with 30 queries by YEKTAWEB 4341