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:: جلد 22، شماره 1 - ( زمستان 1398: 1-201 1398 ) ::
جلد 22 شماره 1 صفحات 71-77 برگشت به فهرست نسخه ها
اثر سیتاگلیپتین بر سطح سرمی TNF-α، IL-1β و IL-10 در بیماران مبتلا به دیابت ملیتوس نوع 2
زهرا تلیکانی ، ویدا شیخ ، علیرضا زمانی ، شیوا برزوئی ، ایرج صالحی ، محمد علی امیرزرگر ، مهدی اله قلی حاجی بهزاد
چکیده:   (454 مشاهده)
هدف: دیابت قندی  نوع دو (Type 2 diabetes mellitus, T2DM) یک بیماری التهابی مزمن همراه با تغییرات سیستم ایمنی می‌باشد. عدم تعادل در سایتوکاین‌ها نقش مهمی در پاتوژنز T2DM بازی می‌کند. هدف از این مطالعه بررسی سطح سرمی سایتوکاین‌های TNF-α، IL-1β و IL-10 و اثر سیتاگلیپتین بر سطح آن‌ها در بیماران T2DM بود.
مواد و روشها: نمونه خون از 60 بیمار T2DM و 30 فرد کنترل جمع‌آوری شد. بیماران بر اساس درمان به دو گروه 30 نفری دریافت‌کننده سیتاگلیپتین (mg/day 100) به‌مدت هشت ماه و غیر دریافت‌کننده سیتاگلیپتین تقسیم شدند. پس از جداسازی نمونه سرم، سطح TNF-α، IL-1β و IL-10 با استفاده از الایزا اندازه‌گیری شد.
یافتهها: سطح سرمی TNF-α در گروه T2DM غیر دریافت‌کننده سیتاگلیپتین نسبت به گروه کنترل افزایش معناداری نشان داد (002/0=p) سطح TNF-α در گروه دریافت‌کننده سیتاگلیپتین در مقایسه با گروه غیر دریافت‌کننده سیتاگلیپتین کاهش معناداری داشت (01/0=p). سطح IL-10 در بیماران غیر دریافت‌کننده سیتاگلیپتین در مقایسه با گروه کنترل کاهش معناداری داشت (003/0=p). سطح IL-10 در گروه دریافت‌کننده سیتاگلیپتین در مقایسه با گروه غیر دریافت‌کننده افزایش معناداری نشان داد (002/0=p). سطح IL-1β در مقایسه بین زیر گروه‌ها و در مقایسه با گروه کنترل تفاوت معناداری نشان نداد.
نتیجهگیری: با مصرف سیتاگلیپتین، کاهش سایتوکاین التهابی TNF-α و در مقابل افزایش سایتوکاین مهاری IL-10 در بیماران مشاهده شد. به نظر می‌رسد سیتاگلیپتین دارای اثرات ضدالتهابی در تنظیم سیستم ایمنی بیماران می‌باشد.
 
واژه‌های کلیدی: دیابت ملیتوس نوع دو، سیتاگلیپتین، سایتوکاین، اینترلوکین 10، اینترلوکین 1 بتا، فاکتور نکروز‌دهنده تومور آلفا
متن کامل [PDF 700 kb]   (169 دریافت)    
نوع مطالعه: پژوهشي | موضوع مقاله: عمومى
دریافت: ۱۳۹۷/۱۱/۱۷ | پذیرش: ۱۳۹۸/۳/۲۷ | انتشار: ۱۳۹۸/۱۰/۱۴
فهرست منابع
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37. [1] Sheikh V, Zamani A, Mahabadi-Ashtiyani E, Tarokhian H, Borzouei S, Alahgholi-Hajibehzad M. Decreased regulatory function of CD4(+)CD25(+)CD45RA(+) T cells and impaired IL-2 signalling pathway in patients with type 2 diabetes mellitus. Scand J Immunol 2018; 88: e12711. [DOI:10.1111/sji.12711] [PMID]
38. [2] Borzouei S, Sheikh V, Ghasemi M, Zamani A, Telikani Z, Zareighane Z, et al. Anti-Inflammatory Effect of Combined Sitagliptin and Vitamin D3 on Cytokines Profile in Patients with Type 2 Diabetes Mellitus. J Interferon Cytokine Res 2019; 39: 293-301. [DOI:10.1089/jir.2018.0144] [PMID]
39. [3] Donath MY, Shoelson SE. Type 2 diabetes as an inflammatory disease. Nat Rev Immunol 2011; 11: 98-107. [DOI:10.1038/nri2925] [PMID]
40. [4] Wang C, Guan Y, Yang J. Cytokines in the Progression of Pancreatic beta-Cell Dysfunction. Int J Endocrinol 2010; 2010: 515136. [DOI:10.1155/2010/515136] [PMID] [PMCID]
41. [5] Gregor MF, Hotamisligil GS. Inflammatory mechanisms in obesity. Ann Rev Immunol 2011; 29: 415-445. [DOI:10.1146/annurev-immunol-031210-101322] [PMID]
42. [6] Pickup JC. Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care 2004; 27: 813-823. [DOI:10.2337/diacare.27.3.813] [PMID]
43. [7] Navarro-Gonzalez JF, Mora-Fernandez C. The role of inflammatory cytokines in diabetic nephropathy. J Am Soc Nephrol 2008; 19: 433-442. [DOI:10.1681/ASN.2007091048] [PMID]
44. [8] Dinarello CA, Donath MY, Mandrup-Poulsen T. Role of IL-1beta in type 2 diabetes. Curr Opin Endoc Diabetes Obes 2010; 17: 314-321. [DOI:10.1097/MED.0b013e32833bf6dc] [PMID]
45. [9] Alahgholi-Hajibehzad M, Oflazer P, Aysal F, Durmus H, Gulsen-Parman Y, Marx A, et al. Regulatory function of CD4+CD25++ T cells in patients with myasthenia gravis is associated with phenotypic changes and STAT5 signaling: 1,25-Dihydroxyvitamin D3 modulates the suppressor activity. J Neuroimmunol 2015; 281: 51-60. [DOI:10.1016/j.jneuroim.2015.03.008] [PMID]
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47. [11] Alahgholi-Hajibehzad M, Durmus H, Aysal F, Gulsen-Parman Y, Oflazer P, Deymeer F, et al. The effect of interleukin (IL)-21 and CD4(+) CD25(++) T cells on cytokine production of CD4(+) responder T cells in patients with myasthenia gravis. Clin Exp Immunol 2017; 190: 201-207. [DOI:10.1111/cei.13006] [PMID] [PMCID]
48. [12] Sheikh V, Kasapoglu P, Zamani A, Basiri Z, Tahamoli-Roudsari A, Alahgholi-Hajibehzad M. Vitamin D3 inhibits the proliferation of T helper cells, downregulate CD4(+) T cell cytokines and upregulate inhibitory markers. Human Immunol 2018; 79: 439-445. [DOI:10.1016/j.humimm.2018.03.001] [PMID]
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51. [15] Francisco CO, Catai AM, Moura-Tonello SC, Arruda LC, Lopes SL, Benze BG, et al. Cytokine profile and lymphocyte subsets in type 2 diabetes. Braz J Med Biol Res 2016; 49: e5062. [DOI:10.1590/1414-431X20155062] [PMID] [PMCID]
52. [16] Jagannathan-Bogdan M, McDonnell ME, Shin H, Rehman Q, Hasturk H, Apovian CM, et al. Elevated proinflammatory cytokine production by a skewed T cell compartment requires monocytes and promotes inflammation in type 2 diabetes. J Immunol 2011; 186: 1162-1172. [DOI:10.4049/jimmunol.1002615] [PMID] [PMCID]
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63. [27] Pickup JC, Chusney GD, Thomas SM, Burt D. Plasma interleukin-6, tumour necrosis factor α and blood cytokine production in type 2 diabetes. Life Sci 2000; 67: 291-300. [DOI:10.1016/S0024-3205(00)00622-6]
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67. [31] Maedler K, Sergeev P, Ris F, Oberholzer J, Joller-Jemelka HI, Spinas GA, et al. Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets. J Clin Invest 2002; 110: 851-860. [DOI:10.1172/JCI200215318] [PMID] [PMCID]
68. [32] Zhao G, Dharmadhikari G, Maedler K, Meyer-Hermann M. Possible Role of Interleukin-1β in Type 2 Diabetes Onset and Implications for Anti-inflammatory Therapy Strategies. PLoS Comput Biol 2014; 10: e1003798. [DOI:10.1371/journal.pcbi.1003798] [PMID] [PMCID]
69. [33] Spranger J, Kroke A, Mohlig M, Hoffmann K, Bergmann MM, Ristow M, et al. Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Diabetes 2003; 52: 812-817. [DOI:10.2337/diabetes.52.3.812] [PMID]
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Telikani Z, Sheikh V, zamani A, Borzouei S, Salehi I, Amirzargar M A et al . Effect of sitagliptin on serum levels of TNF-α, IL-1β and IL-10 in patients with type 2 diabetes mellitus. koomesh. 2020; 22 (1) :71-77
URL: http://koomeshjournal.semums.ac.ir/article-1-5489-fa.html

تلیکانی زهرا، شیخ ویدا، زمانی علیرضا، برزوئی شیوا، صالحی ایرج، امیرزرگر محمد علی و همکاران.. اثر سیتاگلیپتین بر سطح سرمی TNF-α، IL-1β و IL-10 در بیماران مبتلا به دیابت ملیتوس نوع 2. كومش. 1398; 22 (1) :71-77

URL: http://koomeshjournal.semums.ac.ir/article-1-5489-fa.html



جلد 22، شماره 1 - ( زمستان 1398: 1-201 1398 ) برگشت به فهرست نسخه ها
کومش Koomesh
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