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:: جلد 22، شماره 1 - ( زمستان 1398: 1-201 1398 ) ::
جلد 22 شماره 1 صفحات 170-177 برگشت به فهرست نسخه ها
ارزیابی اثرات عصاره هیدروالکلی پروپولیس ایرانی بر درد حاد، مزمن و احشایی در موش کوچک آزمایشگاهی
عباسعلی طاهریان ، حمیدرضا ثامنی ، شیما شریفی ، محمد مهدی طاهریان ، محمد حسین طاهریان
چکیده:   (397 مشاهده)
هدف: پروپولیس یک محصول طبیعی تولید شده به‌وسیله زنبور عسل است که در طب سنتی برای درمان بیماری‌های متفاوتی مورد استفاده قرار می‌گرفته است. با توجه به خاصیت ضد التهابی گزارش شده از پروپولیس، در این مطالعه اثرات ضد دردی عصاره هیدروالکلی پروپولیس ایرانی به صورت داخل صفاقی بر دردهای حاد، مزمن و احشایی و با استفاده از آزمون‌های ارزیابی دردHot plate Tail flick, Formalin,  و Writhing مورد ارزیابی قرار گرفت.
مواد و روشها: در این‌ مطالعه تجربی 192 سر موش‌ سوری جوان (آلبینو) در محدوده‌ وزنی‌ 25 تا 30 گرم‌ در 24 گروه 8 تایی مورد استفاده قرار گرفتند. عصاره هیدروالکلی پروپولیس ایرانی با دوزهای 100، 200 و 500 میلی‌گرم به ازای هر کیلوگرم وزن بدن موش و وهیکل 30 دقیقه قبل از ارزیابی درد و مرفین به عنوان داروی استاندارد ضد درد، به‌طور داخل صفاقی تزریق شدند. درد حاد و مزمن در آزمون‌های ارزیابی درد Hot Plate و Tail Flick و Formalin و درد احشایی در مدل Writhing مورد بررسی قرار گرفتند.
یافتهها: عصاره پروپولیس ایرانی در  همه دوزها در مقایسه با گروه کنترل سبب افزایش معنی‌داری در زمان تحمل به درد در آزمون‌های Hot Plate  و Tail Flick شد (01/0P<) در آزمون Formalin،  تزریق عصاره پروپولیس در مقایسه با گروه کنترل به صورت معنی‌داری منجر به کاهش درد در هر دو فاز نوروژنیک و التهابی شد (01/0P<) پیش درمانی با عصاره پروپولیس به صورت داخل صفاقی تعداد و زمان انقباضات شکمی را در آزمون Writhing در مقایسه با گروه کنترل کاهش داد (01/0P<).
نتیجهگیری: یافته‌های فوق نشان داد عصاره هیدروالکلی پروپولیس ایرانی دارای اثرات ضد دردی در شرایط دردهای حاد و مزمن دارد.
 
واژه‌های کلیدی: پروپولیس، درد مزمن، درد حاد، درد احشایی، موش کوچک آزمایشگاهی
متن کامل [PDF 779 kb]   (108 دریافت)    
نوع مطالعه: پژوهشي | موضوع مقاله: عمومى
دریافت: ۱۳۹۷/۷/۳۰ | پذیرش: ۱۳۹۸/۵/۸ | انتشار: ۱۳۹۸/۱۰/۱۴
فهرست منابع
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Taherian A A, Sameni H R, Sharifi S, Taherian M H, Taherian M H. Effects of hydroalchoholic extract of Iranian Propolis on acute, chronic and visceral pain in mice. koomesh. 2020; 22 (1) :170-177
URL: http://koomeshjournal.semums.ac.ir/article-1-5246-fa.html

طاهریان عباسعلی، ثامنی حمیدرضا، شریفی شیما، طاهریان محمد مهدی، طاهریان محمد حسین. ارزیابی اثرات عصاره هیدروالکلی پروپولیس ایرانی بر درد حاد، مزمن و احشایی در موش کوچک آزمایشگاهی. كومش. 1398; 22 (1) :170-177

URL: http://koomeshjournal.semums.ac.ir/article-1-5246-fa.html



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