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The effect of oral feeding of Allium ascalonicum L. on thoracic aorta contractile response in diabetic rats
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F. فلاحی   , M. روغنی , A. باقری |
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Abstract: (16235 Views) |
| Introduction: Diabetes mellitus is accompanied with higher incidence of cardiovascular disorders. There is some evidence on antidiabetic potential of Allium ascalonicum L. (AA). Therefore, this study was conducted to evaluate the beneficial effect of oral two-month administration of AA on contractile reactivity of isolated thoracic aorta from diabetic rats.
Materials and Methods: Male Wistar rats were divided into control, AA-treated control, diabetic, and AA-treated diabetic groups. For induction of diabetes, streptozotcin (STZ) was intraperitoneally administered (60 mg/Kg). Meanwhile, treated groups received AA mixed with standard pelleted food at a weight ratio of 6.25% for 2 months. Serum glucose level was measured in weeks 4 and 8. Also after 2 months contractile reactivity of thoracic aortic rings to KCl and noradrenaline was determined using isolated tissue setup.
Results: Serum glucose level showed a significant increase in diabetic animals (p |
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| Keywords: Allium ascalonicum L., Aorta, Diabetes Mellitus, Contractile Response |
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Full-Text [PDF 184 kb]
(3060 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2009/07/7 | Published: 2009/05/15
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