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:: Volume 21, Issue 3 (تابستان 1398 1398) ::
Koomesh 1398, 21(3): 535-539 Back to browse issues page
Rapid repair of skin ulcers in diabetic rats using polycaproplactone /gelatin nanon-fiber scaffold
Fariba Zafari , Morteza Sadeghi , Mehrdad Bakhtiyari , Shahram Teimourian
Abstract:   (4186 Views)
Introduction: Three-dimensional nano scaffolds by creating a three-dimensional structure similar to the body tissues have created a new perspective on cell culture and tissue repair. The aim of this study was to investigate the effect of polycaprolactone biodegradation scaffold (PCL) in treatment of diabetic wounds. Materials and Methods: Nano PCL-Gelatine scaffold was synthesized by electrospun method. A circular wound (6 mm) was created in skin of 15 BALB/c rats and the rats were divided into 3 groups including: Non-diabetic group (sham), Diabetic group without nano scaffold receiving (control) and diabetic group with nano scaffolds (scaffold). Wound surface area and wound healing were evaluated on the 7th and 14th days using H & E staining with Image J and SPSS softwares. Results: On 7th day, the smallest and highest wound surface was observed in the Scaffold and Control groups respectively (P
Keywords: Polycaprolactone, Diabetes Mellitus, Ulcer, Rats
Full-Text [PDF 1360 kb]   (901 Downloads)    
Type of Study: Research | Subject: General
Received: 2018/01/22 | Accepted: 2018/10/17 | Published: 2019/06/16
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Zafari F, Sadeghi M, Bakhtiyari M, teimourian S. Rapid repair of skin ulcers in diabetic rats using polycaproplactone /gelatin nanon-fiber scaffold. Koomesh 1398; 21 (3) :535-539
URL: http://koomeshjournal.semums.ac.ir/article-1-4578-en.html


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Volume 21, Issue 3 (تابستان 1398 1398) Back to browse issues page
کومش Koomesh
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