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:: Volume 22, Issue 1 (زمستان 1398) ::
Koomesh 1398, 22(1): 155-163 Back to browse issues page
Effects of 12 weeks of combined aerobic-resistance exercise training on levels of chemerin, omentin and insulin resistance in men with type 2 diabetes
Mehdi Zarei , Seyed Mehdi Beheshti Beheshti Nasr , Mohammadreza Hamedinia , Hossein Taheri Chadorneshin , Hesamedin Askari Majdabadi
Abstract:   (4992 Views)
Introduction: Regular exercise training has been shown to be a useful option to treat and prevent type 2 diabetes. Correspondingly, the purpose of this study was to investigate effects of 12 weeks of combined aerobic-resistance exercise training on levels of chemerin, omentin and insulin resistance in men with type 2 diabetes. Materials and Methods: In this clinical trial research, 20 male patients with type 2 diabetes were randomly divided into two groups combined aerobic-resistance training (n=10) and control (n=10). Subjects in training group performed 12 weeks aerobic-resistance training, 3 weekly training sessions with given intensity (aerobic: intensity of 60-70% maximum heart rate resistance: intensity 60-70% repetition maximum). Blood sampling was taken measurements of for chemerin, omentin resistance, fasting glucose and insulin resistance in the beginning and after 12 training protocol weeks were conducted. Results: After 12 weeks, in the combined training group chemerin (p=0.01), resistance insulin (p=0.01) and fasting glucose (p=0.001) decreased significantly and Vo2max increased significantly (p=0.001) than the control group. Significant change was not observed at the levels of omentin (p=0.37). Conclusion: 12 weeks of aerobic-resistance training in men with type 2 diabetes decreased the levels of chemerin, insulin resistance and also fasting glucose, but did not affect the level of omentin.  
Keywords: Exercise, Diabetes Mellitus Type 2, Insulin Resistance, Chemerin Protein, Omentin Protein
Full-Text [PDF 648 kb]   (1223 Downloads)    
Type of Study: Research | Subject: General
Received: 2017/08/12 | Accepted: 2019/06/15 | Published: 2020/01/4
References
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19. [19] Banitalebi E, Shahrekordi ZM, Kazemi AR, Bagheri L, Shalamzari SA, Faramarzi M. Comparing the effects of eight weeks of combined training (Endurance and Resistance) in different orders on inflammatory factors and adipokines among elderly females. Women's Health Bulletin 2016; 3. (Persian). [DOI:10.17795/whb-30990]
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21. [21] Saremi A, Asghari M, Ghorbani A. Effects of aerobic training on serum omentin-1 and cardiometabolic risk factors in overweight and obese men. J sports sci 2010; 28: 993-998. [DOI:10.1080/02640414.2010.484070] [PMID]
22. [22] Jackson AS, Pollock ML. Practical assessment of body composition. Physician Sports Med 1985; 13: 76-90. [DOI:10.1080/00913847.1985.11708790] [PMID]
23. [23] Sarafidis PA, Lasaridis AN, Nilsson PM, Pikilidou MI, Stafilas PC, Kanaki A, et al. Validity and reproducibility of HOMA-IR, 1/HOMA-IR, QUICKI and McAuley's indices in patients with hypertension and type II diabetes. J Hum Hypertens 2007; 21: 709-716. [DOI:10.1038/sj.jhh.1002201] [PMID]
24. [24] Jafari M, Mogharnasi M, Salimi Khorashad A. Effects of endurance and resistance training on plasma levels of chemerin and factors related to obesity in overweight and obese females. Armaghane Danesh 2015; 20: 273-286. (Persian).
25. [25] Neuparth MJo, Proenأ§a JBo, Santos-Silva A, Coimbra S. The positive effect of moderate walking exercise on chemerin levels in Portuguese patients with type 2 diabetes mellitus. J Investig Med 2014; 62: 350-353. [DOI:10.2310/JIM.0000000000000025] [PMID]
26. [26] Sell H, Laurencikiene J, Taube A, Eckardt K, Cramer A, Horrighs A, et al. Chemerin is a novel adipocyte-derived factor inducing insulin resistance in primary human skeletal muscle cells. Diabetes 2009; 58: 2731-2740. [DOI:10.2337/db09-0277] [PMID] [PMCID]
27. [27] Goralski KB, McCarthy TC, Hanniman EA, Zabel BA, Butcher EC, Parlee SD, et al. Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism. J Biol Chem 2007; 282: 28175-28888. [DOI:10.1074/jbc.M700793200] [PMID]
28. [28] Kaur J, Adya R, Tan BK, Chen J, Randeva HS. Identification of chemerin receptor (ChemR23) in human endothelial cells: chemerin-induced endothelial angiogenesis. Biochem Biophys Res Commun 2010; 391: 1762-1768. [DOI:10.1016/j.bbrc.2009.12.150] [PMID]
29. [29] Chang HM, Park HS, Park C-Y, Song YS, Jang YJ. Association between serum vaspin concentrations and visceral adipose tissue in Korean subjects. Metabolism 2010; 59: 1276-1281. [DOI:10.1016/j.metabol.2009.11.021] [PMID]
30. [30] Malin SK, Navaneethan SD, Mulya A, Huang H, Kirwan JP. Exercise-induced lowering of chemerin is associated with reduced cardiometabolic risk and glucose-stimulated insulin secretion in older adults. J Nutr Health Aging 2014; 18: 608-615. [DOI:10.1007/s12603-014-0459-7] [PMID] [PMCID]
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32. [32] Daryanoosh F, Aminilari Z. The effect of 12 weeks of resistance training on the Apelin, Omentin-1 levels and insulin resistance in the elderly overweight women with type 2 diabetes. ZUMS Journal 2015; 23: 29-40.
33. [33] Moreno-Navarrete JM, Catalan V, Ortega F, Gomez-Ambrosi J, Ricart W, Fruhbeck G, Fernondez-Real JM. Circulating omentin concentration increases after weight loss. Nutr Metab (Lond) 2010; 7: 27. [DOI:10.1186/1743-7075-7-27] [PMID] [PMCID]
34. [34] Yan P, Li L, Yang M, Liu D, Liu H, Boden G, Yang G. Effects of the long-acting human glucagon-like peptide-1 analog liraglutide on plasma omentin-1 levels in patients with type 2 diabetes mellitus. Diabetes Res Clin Pract 2011; 92: 368-374. [DOI:10.1016/j.diabres.2011.02.030] [PMID]
35. [35] Gürsoy G, Kırnap NG, Eşbah O, Acar Y, Demirbaş B, Akçayöz S, Öztürk A. The relationship between plasma omentin-1 levels and insulin resistance in newly diagnosed type 2 diabetic women. Clin Rev Opinions 2010; 2: 49-54.
36. [36] Pan HY, Guo L, Li Q. Changes of serum omentin-1 levels in normal subjects and in patients with impaired glucose regulation and with newly diagnosed and untreated type 2 diabetes. Diabetes Res Clin Pract 2010; 88: 29-33. [DOI:10.1016/j.diabres.2010.01.013] [PMID]
37. [37] Balducci S, Zanuso S, Nicolucci A, Fernando F, Cavallo S, Cardelli P, et al. Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight loss. Nutr Metab Cardiovasc Dis 2010; 20: 608-617. [DOI:10.1016/j.numecd.2009.04.015] [PMID]
38. [38] Liu Y, Liu SX, Cai Y, Xie KL, Zhang WL, Zheng F. Effects of combined aerobic and resistance training on the glycolipid metabolism and inflammation levels in type 2 diabetes mellitus. J Phys Ther Sci 2015; 27: 2365-2371. [DOI:10.1589/jpts.27.2365] [PMID] [PMCID]
39. [39] Samadian Z, tofighi A, Mahdi zadeh A. Effect of combined training (aerobic- resistance) on resistine serum and glycemic indexes in type 2 diabetes obese postmenopausal women. Iran J Diabetes Metab 2013; 12: 524-533.
40. [40] Jorge ML, de Oliveira VN, Resende NM, Paraiso LF, Calixto A, Diniz AL, et al. The effects of aerobic, resistance, and combined exercise on metabolic control, inflammatory markers, adipocytokines, and muscle insulin signaling in patients with type 2 diabetes mellitus. Metabolism 2011; 60: 1244-1252. [DOI:10.1016/j.metabol.2011.01.006] [PMID]
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46. [46] Hamedinia MR, Amiri PT, Khademosharie M, Azarnive MS, Hedayati M. The effect of five-week daily aerobic exercise training and ten-week every other day aerobic training on some markers of women with type 2 diabetes. 2012.
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48. [2] Hordern MD, Dunstan DW, Prins JB, Baker MK, Singh MAF, Coombes JS. Exercise prescription for patients with type 2 diabetes and pre-diabetes: a position statement from Exercise and Sport Science Australia. J Sci Med Sport 2012; 15: 25-31. [DOI:10.1016/j.jsams.2011.04.005] [PMID]
49. [3] Khamseh ME, Abdi H, Malek M, Shafiee G, Khodakarim S. Relationship between patients' perception of the importance of diabetes and metabolic control and pursuing chronic complications of disease. Koomesh 2011; 12: 334-341.
50. [4] Hajihasani A, Bakhtiari AH, Taghikhani M. Effects of eccentric and concentric exercises on some blood biochemical parameters in patients with type 2 diabetes. Koomesh 2012; 338-344.
51. [5] Han J, Kim SH, Suh YJ, Lim H, Shin H, Cho SG, et al. Serum chemerin levels are associated with abdominal visceral fat in type 2 diabetes. J Korean Med Sci 2016; 31: 924-931. [DOI:10.3346/jkms.2016.31.6.924] [PMID] [PMCID]
52. [6] Lago F, Gómez R, Gómez-Reino JJ, Dieguez C, Gualillo O. Adipokines as novel modulators of lipid metabolism. Trends Biochem Sci 2009; 34: 500-510. [DOI:10.1016/j.tibs.2009.06.008] [PMID]
53. [7] Chakaroun R, Raschpichler M, Klöting N, Oberbach A, Flehmig G, Kern M, et al. Effects of weight loss and exercise on chemerin serum concentrations and adipose tissue expression in human obesity. Metabolism 2012; 61: 706-714. [DOI:10.1016/j.metabol.2011.10.008] [PMID]
54. [8] Saghebjoo M, Shabanpoor Omali J, Fathi R. Effects of 8 weeks high intensity circuit resistance training on plasma chemerin levels and glycemic control in male patients with type 2 diabetes. Olympic 2013; 21: 99-113.
55. [9] Wittenbecher C, Menzel J, Carstensen-Kirberg M, Biemann R, di Giuseppe R, Fritsche A, et al. Omentin-1, adiponectin, and the risk of developing type 2 diabetes. Diabetes Care 2016; 39: e79-e80. [DOI:10.2337/dc15-2702] [PMID]
56. [10] Fathi R, Nazar Ali p, Adabi Z. Effect of 8 weeks of resistance training on omentin level and resistance insulin in obese and overweight women. J Appl Sport Physiol 2014; 10: 109-120.
57. [11] Hong HR, Jeong JO, Kong JY, Lee SH, Yang SH, Ha CD, Kang HS. Effect of walking exercise on abdominal fat, insulin resistance and serum cytokines in obese women. J Exerc Nutr Biochem 2014; 18: 277. [DOI:10.5717/jenb.2014.18.3.277] [PMID] [PMCID]
58. [12] Oliveira C, Simões M, Carvalho J, Ribeiro J. Combined exercise for people with type 2 diabetes mellitus: a systematic review. Diabetes Res Clin Pract 2012; 98: 187-198. [DOI:10.1016/j.diabres.2012.08.004] [PMID]
59. [13] Praet SFE, Van Loon LJC. Optimizing the therapeutic benefits of exercise in type 2 diabetes. J Appl Physiol (1985) 2007; 103: 1113-1120. [DOI:10.1152/japplphysiol.00566.2007] [PMID]
60. [14] Yarahmadi H, Haghighi AH, Shojaei M, Beheshti Nasr SM. Effect of nine weeks of moderate aerobic training on insulin resistance and appetite level in obese women. Quarterly Horizon Med Sci 2014; 20: 9-16.
61. [15] Faramarzi M, Banitalebi E, Nori S, Farzin S, Taghavian Z. Effects of rhythmic aerobic exercise plus core stability training on serum omentin, chemerin and vaspin levels and insulin resistance of overweight women. J Sports Med Phys Fitness 2016; 56: 476-482.
62. [16] Khademosharie M, Amiri Parsa T, Hamedinia MR, Hosseini-Kakhk SAR. Effects of two aerobic training protocols on Vaspin, Chemerin and lipid profile in women with type 2 diabetes. ISMJ 2014; 17: 571-81. [DOI:10.33883/jms.v17i1.227]
63. [17] Stefanov T, Blüher M, Vekova A, Bonova I, Tzvetkov S, Kurktschiev D, Temelkova-Kurktschiev T. Circulating chemerin decreases in response to a combined strength and endurance training. Endocrine 2014; 45: 382-391. [DOI:10.1007/s12020-013-0003-2] [PMID]
64. [18] Askari R, Ravasi AA, Gaeini AA, Hedayati M, Hamedinia MR. The effect of combined exercise training on some adipokines and insulin sensitivity index in overweight females. J Sport Biomotor Sci 2011; 1: 25-36.
65. [19] Banitalebi E, Shahrekordi ZM, Kazemi AR, Bagheri L, Shalamzari SA, Faramarzi M. Comparing the effects of eight weeks of combined training (Endurance and Resistance) in different orders on inflammatory factors and adipokines among elderly females. Women's Health Bulletin 2016; 3. (Persian). [DOI:10.17795/whb-30990]
66. [20] Ghanbarzadeh M, Kazemi A. The comparison of three different concurrent training on chemerin plasma levels, insulin resistance and physical performance of older women. J Knowledge Health 2016; 10: 40-47. (Persian).
67. [21] Saremi A, Asghari M, Ghorbani A. Effects of aerobic training on serum omentin-1 and cardiometabolic risk factors in overweight and obese men. J sports sci 2010; 28: 993-998. [DOI:10.1080/02640414.2010.484070] [PMID]
68. [22] Jackson AS, Pollock ML. Practical assessment of body composition. Physician Sports Med 1985; 13: 76-90. [DOI:10.1080/00913847.1985.11708790] [PMID]
69. [23] Sarafidis PA, Lasaridis AN, Nilsson PM, Pikilidou MI, Stafilas PC, Kanaki A, et al. Validity and reproducibility of HOMA-IR, 1/HOMA-IR, QUICKI and McAuley's indices in patients with hypertension and type II diabetes. J Hum Hypertens 2007; 21: 709-716. [DOI:10.1038/sj.jhh.1002201] [PMID]
70. [24] Jafari M, Mogharnasi M, Salimi Khorashad A. Effects of endurance and resistance training on plasma levels of chemerin and factors related to obesity in overweight and obese females. Armaghane Danesh 2015; 20: 273-286. (Persian).
71. [25] Neuparth MJo, Proenأ§a JBo, Santos-Silva A, Coimbra S. The positive effect of moderate walking exercise on chemerin levels in Portuguese patients with type 2 diabetes mellitus. J Investig Med 2014; 62: 350-353. [DOI:10.2310/JIM.0000000000000025] [PMID]
72. [26] Sell H, Laurencikiene J, Taube A, Eckardt K, Cramer A, Horrighs A, et al. Chemerin is a novel adipocyte-derived factor inducing insulin resistance in primary human skeletal muscle cells. Diabetes 2009; 58: 2731-2740. [DOI:10.2337/db09-0277] [PMID] [PMCID]
73. [27] Goralski KB, McCarthy TC, Hanniman EA, Zabel BA, Butcher EC, Parlee SD, et al. Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism. J Biol Chem 2007; 282: 28175-28888. [DOI:10.1074/jbc.M700793200] [PMID]
74. [28] Kaur J, Adya R, Tan BK, Chen J, Randeva HS. Identification of chemerin receptor (ChemR23) in human endothelial cells: chemerin-induced endothelial angiogenesis. Biochem Biophys Res Commun 2010; 391: 1762-1768. [DOI:10.1016/j.bbrc.2009.12.150] [PMID]
75. [29] Chang HM, Park HS, Park C-Y, Song YS, Jang YJ. Association between serum vaspin concentrations and visceral adipose tissue in Korean subjects. Metabolism 2010; 59: 1276-1281. [DOI:10.1016/j.metabol.2009.11.021] [PMID]
76. [30] Malin SK, Navaneethan SD, Mulya A, Huang H, Kirwan JP. Exercise-induced lowering of chemerin is associated with reduced cardiometabolic risk and glucose-stimulated insulin secretion in older adults. J Nutr Health Aging 2014; 18: 608-615. [DOI:10.1007/s12603-014-0459-7] [PMID] [PMCID]
77. [31] Aminilari Z, Daryanoosh F, Kooshki JM, Mohamadi M. The effect of 12 weeks aerobic exercise on the apelin, omentin and glucose in obese older women with diabetes type 2. 2014.
78. [32] Daryanoosh F, Aminilari Z. The effect of 12 weeks of resistance training on the Apelin, Omentin-1 levels and insulin resistance in the elderly overweight women with type 2 diabetes. ZUMS Journal 2015; 23: 29-40.
79. [33] Moreno-Navarrete JM, Catalan V, Ortega F, Gomez-Ambrosi J, Ricart W, Fruhbeck G, Fernondez-Real JM. Circulating omentin concentration increases after weight loss. Nutr Metab (Lond) 2010; 7: 27. [DOI:10.1186/1743-7075-7-27] [PMID] [PMCID]
80. [34] Yan P, Li L, Yang M, Liu D, Liu H, Boden G, Yang G. Effects of the long-acting human glucagon-like peptide-1 analog liraglutide on plasma omentin-1 levels in patients with type 2 diabetes mellitus. Diabetes Res Clin Pract 2011; 92: 368-374. [DOI:10.1016/j.diabres.2011.02.030] [PMID]
81. [35] Gürsoy G, Kırnap NG, Eşbah O, Acar Y, Demirbaş B, Akçayöz S, Öztürk A. The relationship between plasma omentin-1 levels and insulin resistance in newly diagnosed type 2 diabetic women. Clin Rev Opinions 2010; 2: 49-54.
82. [36] Pan HY, Guo L, Li Q. Changes of serum omentin-1 levels in normal subjects and in patients with impaired glucose regulation and with newly diagnosed and untreated type 2 diabetes. Diabetes Res Clin Pract 2010; 88: 29-33. [DOI:10.1016/j.diabres.2010.01.013] [PMID]
83. [37] Balducci S, Zanuso S, Nicolucci A, Fernando F, Cavallo S, Cardelli P, et al. Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight loss. Nutr Metab Cardiovasc Dis 2010; 20: 608-617. [DOI:10.1016/j.numecd.2009.04.015] [PMID]
84. [38] Liu Y, Liu SX, Cai Y, Xie KL, Zhang WL, Zheng F. Effects of combined aerobic and resistance training on the glycolipid metabolism and inflammation levels in type 2 diabetes mellitus. J Phys Ther Sci 2015; 27: 2365-2371. [DOI:10.1589/jpts.27.2365] [PMID] [PMCID]
85. [39] Samadian Z, tofighi A, Mahdi zadeh A. Effect of combined training (aerobic- resistance) on resistine serum and glycemic indexes in type 2 diabetes obese postmenopausal women. Iran J Diabetes Metab 2013; 12: 524-533.
86. [40] Jorge ML, de Oliveira VN, Resende NM, Paraiso LF, Calixto A, Diniz AL, et al. The effects of aerobic, resistance, and combined exercise on metabolic control, inflammatory markers, adipocytokines, and muscle insulin signaling in patients with type 2 diabetes mellitus. Metabolism 2011; 60: 1244-1252. [DOI:10.1016/j.metabol.2011.01.006] [PMID]
87. [41] Tan S, Li W, Wang J. Effects of six months of combined aerobic and resistance training for elderly patients with a long history of type 2 diabetes. J Sports Sci Med 2012; 11: 495-501.
88. [42] Yavari A, Najafipoor F, Aliasgarzadeh A, Niafar M, Mobasseri M. Effect of aerobic exercise, resistance training or combined training on glycaemic control and cardiovascular risk factors in patients with type 2 diabetes. Biology Sport 2012; 29: 135. [DOI:10.5604/20831862.990466]
89. [43] Church TS, Blair SN, Cocreham S, Johannsen N, Johnson W, Kramer K, et al. Effects of aerobic and resistance training on hemoglobin A1c levels in patients with type 2 diabetes: a randomized controlled trial. JAMA 2010; 304: 2253-2262. [DOI:10.1001/jama.2010.1710] [PMID] [PMCID]
90. [44] Marcus RL, Smith S, Morrell G, Addison O, Dibble LE, Wahoff-Stice D, LaStayo PC. Comparison of combined aerobic and high-force eccentric resistance exercise with aerobic exercise only for people with type 2 diabetes mellitus. Phys Ther 2008; 88: 1345-1354. [DOI:10.2522/ptj.20080124] [PMID] [PMCID]
91. [45] Albright A, Franz M, Hornsby G, Kriska A, Marrero D, Ullrich I, Verity LS. American College of Sports Medicine position stand. Exercise and type 2 diabetes. Med Sci Sports Exerc 2000; 32: 1345-1360. [DOI:10.1097/00005768-200007000-00024] [PMID]
92. [46] Hamedinia MR, Amiri PT, Khademosharie M, Azarnive MS, Hedayati M. The effect of five-week daily aerobic exercise training and ten-week every other day aerobic training on some markers of women with type 2 diabetes. 2012.
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Zarei M, Beheshti Nasr S M B, Hamedinia M, Taheri Chadorneshin H, Askari Majdabadi H. Effects of 12 weeks of combined aerobic-resistance exercise training on levels of chemerin, omentin and insulin resistance in men with type 2 diabetes. Koomesh 1398; 22 (1) :155-163
URL: http://koomeshjournal.semums.ac.ir/article-1-4195-en.html


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Volume 22, Issue 1 (زمستان 1398) Back to browse issues page
کومش Koomesh
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