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The effect of burn on cell mediated immunity
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P. کوخایی   , Z. محمدحسن , H. مطیعیان , F. پاک |
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Abstract: (16821 Views) |
| Introduction. In spite of new development in antibiotic production, infections are the
main causes of death after burn injuries. This is due to skin destruction as the first
defense barrier abd alteration in immune status of the burn patient. In this study, the
effect of burn on cell medi ated immunity was studied.
Material and Methods. Two groups were studied: experienta l group consist ing of lS
patie nt ( 9 men and 9 woman ) with 20-60% burn of total body surface are and control
gro up consisting 22 ( 11 men and 11 woman ) healthy persons . The average age of both
group was 32 years and in each group subjects were equ al of boyh sexes. Immune sta tus
was evaluated by T lymphocyte transformation test ( L.T.T) and HLA-DR as a cell
activati on marker and also cell surface marker such as CD3, CD4 and CDS which are
measured by monoclonal antibody and tlowcytometric analysis.
Results. L.T.T of burned patients was significantly de crased in comparison of control
grou p ( P< 0.0001). The tota l number of peri pheral bloob lymphocytes of burned
patients was significantly lower than th at of control gro up (P |
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| Keywords: Immunity, Burn, T-cells, B-cells |
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Full-Text [PDF 784 kb]
(2226 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2009/02/4 | Published: 1999/11/15
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