اکثر مکاتبات کومش از طریق ایمیل سایت می باشد. لطفا Spam ایمیل خود را نیز چک نمایید.
   [Home ] [Archive]   [ فارسی ]  
:: ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
Subscription::
Contact us::
Site Facilities::
Webmail::
Editorial Board::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
:: Volume 19, Issue 4 ( (پياپی 68)، پائیز 1396) ::
Koomesh 1396, 19(4): 774-784 Back to browse issues page
Detection of prostate cancer biomarker using optical nanobiosensor based on gold nanoparticle
Zahra Akbari jonoush , Reza Mansori , Fatemeh Yazdiyan , Meisam Omidi
Abstract:   (5190 Views)
Introduction: Nowadays, early cancer detection and effective treatment is crucial for improved prognosis and cancer management and therefore, identification of sensitive and specific methods for early cancer detection is required. One of the methods for early cancer detection is biosensor and gold nanoparticles. The aim of this study was to examine total prostate specific antigen (PSA) biomarker using by nanobio-optical sensor. Materials and Methods: Herein, antibody coated gold nanoparticles was employed in optical immunoassay for detecting of total PSA biomarker. To achieve the goal, antibody was covalently conjugated to gold Nano spheres using 11-Mercaptoundecanoic acid (MUA). Finally, sample serum was investigated by LSPR (localized surface Plasmon resonances) and finally, the results obtained by LSPR and CLIA (Chemiluminescence assay (were compared with each other. Results: The results suggested that nano bio-optical sensor had good potential and good sensitivity in detecting of total PSA. Notably, the proposed nanobio-optical sensor delivered a good sensitivity with average sensitivity 1.1 ng/ml, and a low detection limit of o.9 ng/ml. Conclusion: These results indicate that the nnobio-optical sensor has a great potential in diagnosis of cancer biomarkers.  
Keywords: Nanobio-optical Sensor, Prostate specific Antigen, Biomarker, total PSA Monoclonal Antibody
Full-Text [PDF 759 kb]   (1356 Downloads)    
Type of Study: Research | Subject: General
Received: 2016/08/7 | Accepted: 2017/06/18 | Published: 2017/10/2
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Akbari jonoush Z, Mansori R, yazdiyan F, omidi M. Detection of prostate cancer biomarker using optical nanobiosensor based on gold nanoparticle. Koomesh 1396; 19 (4) :774-784
URL: http://koomeshjournal.semums.ac.ir/article-1-3475-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 19, Issue 4 ( (پياپی 68)، پائیز 1396) Back to browse issues page
کومش Koomesh
Persian site map - English site map - Created in 0.05 seconds with 38 queries by YEKTAWEB 4657