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Quantitative age related changess in the nucleus raphe dorsalis of the rat
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M. H. تبریزی امجد   |
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Abstract: (11934 Views) |
| Introduction. About 50% of serotonergic neurons of the CN.s exist in th e dorsal
ra phe nucle us. To cha nge the seroto nin's ra te of C N.S indu ces man y disorde rs. Due to
age increase. morphologic cha nges in number and diamet er of den drit es. numbe r of
their spines, numbe r of fibers a nd ce llula r endings in the nucleus raphe dorsa lis a nd rate
of their sta ining are observed. T he aim of thi s research is to survey of a ny cha nges in
ne uron s numbers a nd volume of nucleus ra ph e dorsalis in ag ing.
Materials and Methods. In this research 15 fe ma le a lbino rats with age of 3 days. 2
and 12 months were used. T he brain of these rats fixed by pe rfusio n method with
BOEI N solution, th en the spe cimens st ain ed by Cluve r and Barrera me thod. The
number of ce lls and volume of the nucle us raphe dorsa lis have been calculate d hy using
eye pe ace micros cope. T he dat a were a na lysed by Kraskul-Wallis test and P < 0.05 was
conside re d as significa nt.
Results. Micros copic exa mina tio ns have heen show n that with incr easi ng age the
number of neurons of the nucleus ra phe dorsalis and the volume of them significa ntly
dec reased (P< 0.05).
Conclusion. T hese q uantitative changes in higher ages. make the negative effects in
vita l ac tivity of the ne uro ns, which may indu ce many disorde rs. |
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| Keywords: Nucle us Raph e Dor sal is: Reticular Formation, Seroton ergic System, Age Relat ed Cha nges |
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Full-Text [PDF 760 kb]
(1890 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2009/01/21 | Published: 2000/08/15
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