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Role of brain-derived neurotrophic factor receptor on the anxiety levels in rats following the acute administration of morphine
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Masoumeh Khalil-Khalili   , Shahrbanoo Ghodrati-Jaldbakhan , A. li Rashidy-Pour  , Ahmad Reza Bandegi , Behpoor Yousefi , Hossein Miladi-Gorji |
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Abstract: (4725 Views) |
| Introduction: The aim of this study was to examine anxiolytic effects of acute morphine and the role of BDNF receptor on that effect in adult rats.
Materials and Methods: In this experiment, 48 adult male Wistar rats (200–250 g) were randomly assigned to six groups. Rats were given an acute dose of morphine (10 mg/kg, s.c.) and after 2hours, single dose of ANA12 (BDNF receptor antagonist) was injected (0.25, 0.5 mg/kg, i.p). After 4h, rats were examined in the EPM to assess the level of their anxiety. Control rats similarly received saline.
Results: An increase was observed in the percentage of time spent in the open arm in the saline rats receiving ANA12 injection. However, the number of open or closed arm entries was less and more, respectively, in the morphine rats receiving ANA12 injection.
Conclusion: Our findings showed a modulatory role of BDNF/TrkB receptor in the anxiolytic effects of acute morphine. |
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| Keywords: Acute Morphine, BDNF Receptor Antagonist (ANA12), Anxiety |
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Full-Text [PDF 642 kb]
(1258 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2016/02/2 | Accepted: 2016/03/8 | Published: 2016/03/17
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