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Dagnostic and prognostic value of cardiac troponin I measurement with qualitative and quantitative methods in acute yocardial infarction and unstable angina
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M. آقاجانی   |
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Abstract: (55410 Views) |
| Introduction: The insufficient specificity and sensitivity of clinical manifestations, ECG and
common cardiac biomarkers, such as CK, CK-MB and LDH, caused problems in diagnosis of
acute myocardoial infraction (AMI) and make some patients not be diagnosed and completely
treated. To improve the management of patients with acute coronary syndrome (ACS) and
reduce hospitalization, rapid and bed side measurements of new cardiac biomarkers are
interested and investigated.
Materials and Methods: In this study, 208 patients with ACS were involved. The clinical
findings, ECG and level of cardiac enzymes including LDH, CK-MB, total CK, quantitative and
qualitative cardiac troponin-I (CTN-I) were recorded on admission (time 0),12 and 24 hours
there after. Complications of each patient were recorded during hospitalization.
Results: There was no typical angina pectoris (11 %) no typical diagnostic ECG changes
(41 %) (3% were completely normal) no increasing in total CK (12%) and CK-MB (8%) in
patients with AMI so, common cardiac biomarkers leads to fault in diagnosis of some of these
patients, while CTNI was an ideal diagnostic biomarker, because of its high sensitivity (100%)
and specificity (99%). There was a significant relation between increasing CTNI and cardiac
complication, specifically, arrhythmia in AMI cases that indicate the hight risk patients. Also
CTNI was a marker of reperfusion. In 13% of unstable angina cases, CTN-I slightly increased,
indicating the high risk group. The sensitivity and specificity of quantitative measurement of
CTN-I was slightly higher than qualitative method.
Conclusion: CTN-I was more cost effective with high diagnostic and prognostic value, as
compared with the other biomarkers so routinely quantitative or qualitative measurement of
CTN-I, on admission (time 0),12 and 24 hours thereafter is recommended in ACS patients,
instead of other biomarkers. |
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| Keywords: Acute myocardoial infraction, Acute coronary syndrome, Unstable angina |
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Full-Text [PDF 1272 kb]
(3316 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2009/01/5 | Published: 2002/02/15
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