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:: Volume 17, Issue 2 (جلد 17 (2). پياپی (58). زمستان 1394 1394) ::
Koomesh 1394, 17(2): 411-418 Back to browse issues page
Effects of forced exercise on neuropathic pain induced by chronic constriction injury of sciatic nerve in male rat
Hossein Ali Safakhah , Atiye Bazargani , A. li Ghanbari
Abstract:   (6540 Views)
Introduction: Central and peripheral nerve injuries may lead to chronic neuropathic pain in addition to immobility in many injured persons. Exercise as a non-medical procedure has beneficial effects on the well being of individuals in normal and diseased state. Therefore, in the current study we aimed to measure the alleviating effect of physical exercise on neuropathic pain. Materials and Methods: Male wistar rats weighting 200±20 gram were divided into 5 groups: Intact, sham, neuropathic, exercise before neuropathy, and exercise after neuropathy. After anesthesia, rats underwent chronic constriction injury (CCI) procedure to induce neuropathic injury on the left sciatic nerve. After surgery animals were transferred to individual cages and covered with a towel to prevent hypothermia until regaining consciousness. Mechanical allodynia and thermal hyperalgesia were detected using von Frey Filament and Plantar test, respectively. Results: Mechanical and thermal withdrawal response thresholds were reduced significantly (P
Keywords: Constriction, Exercise, Hyperalgesia, Neuralgia, Rats
Full-Text [PDF 681 kb]   (1891 Downloads)    
Type of Study: Research | Subject: General
Received: 2015/07/30 | Accepted: 2015/10/21 | Published: 2015/12/14
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safakhah H A, Bazargani A, Ghanbari A L. Effects of forced exercise on neuropathic pain induced by chronic constriction injury of sciatic nerve in male rat. Koomesh 1394; 17 (2) :411-418
URL: http://koomeshjournal.semums.ac.ir/article-1-2969-en.html


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Volume 17, Issue 2 (جلد 17 (2). پياپی (58). زمستان 1394 1394) Back to browse issues page
کومش Koomesh
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