|
A comparative study on the anticonvulsive effects of the aqueous extrract ot the Rosmarinus officinalis plant with phenobarbitaln pentylentetrazol-induced seizures in mice
|
M. T. بروشکی   , F. ملک , A. بهارلو |
|
|
|
Abstract: (14476 Views) |
| Introduction: The co nvulsive dis orders are among chro nic diseases, whic h usu ally need a
long-term drug the rapy. Unfortunately, most of the drugs used clinically to treat disorde rs exer t
many side effects. Therefore, searc h fo r finding new drugs is being carried o ut in many
laboratories. The object of this research is a comparative study on the anticonvulsive effect of
the aqueo us ext ract o f the plan t R osmarinu s offici na li s wit h p he no barbital in
pentyleneterazol-induced seizures in mice.
Materials and Methods: After acclimatizatio n, animals were randomly divided in different
groups. Control group received normal saline (6 ml/kg), stan dard groups received (10, 20, 30 and
40 mg/kg ) phenobarbital and the test groups received aqueous plant extract (3, 6, 9 and 12
nil/kg). All injections were carried out as i.p. All animals were firstly exposed to pentylentetrazol
(80 mg/kg, i.p). The onset of seizures, behaviora l changes, duration of the seizures and number
of death were reco rded in all groups during the first 24 hours .
Results: Results showed that all amounts of the plant extr acts delay the onse t of seizures but
the most effective dose was 12 ml/kg , which was comparable to pheno ba rbital (30 mg/kg ). All
amount of the extract, except 3 ml/kg, significantly reduced the dura tion of seizu res, compared
to the contro l group. Number of death was 45, 0 and 10 percent in control, sta ndard and test
group respect ively.
Conclusion: Findings showed that 12 mllkg of the aqueous plant extract is able to reduce
the o nse t o f se izu re s, dur at ion of se izu re s and number o f death a ft er 24 hours in
pentylentetrazol-induced seizures. |
|
| Keywords: Rosemarinus officinalis: Pentylentetrazol, Phenobarbital, Seizure |
|
|
Full-Text [PDF 973 kb]
(2215 Downloads)
|
Type of Study: Research |
Subject:
General
Received: 2008/12/30 | Published: 2002/02/15
|
|
|
|
|
|
|
| Send email to the article author |
|
|
|
| Add your comments about this article |
|
|
|
