|
Effect of 17 beta-estradiol on wound healing in overiectomized rats
|
M. شهابی نژاد   , M. خاکساری |
|
|
|
Abstract: (15586 Views) |
| Introduction: In addition to their actions on reproductive function, estrogen has important
effect on neovascvlarization, proliferation of cells and increase of growth hormone secretion. In
this study, the possible effects of 17-b estradio l on cutaneous wound re pair in ovariectomized
rats were evaluated.
Materials and Methods: This experimental study performed on eighty adult female rats .
After anaesthesia, all animals were ovariectomized, and they we re ran domly divided into 6
gro ups (n = 12 in e ach group). Group I and II (co nt rol groups) received daily topically or
subcuta neous injections of 0.1 ml of sesamin oil (vehicle) , respectively. Group III and IV treated
once dialy with 17-b est radiol valerate ointment (10, and 25 mg/kg, respectively). Group V and
VI re cevie d daily subcutaneous inje ct ion of 17-b estr adiol valerate on the day of wounding.
After aneasthesia, full thickness skin of upper dors al pa rt of the rats removed in 3 cm2 ar ea.
Wound surface area measured in I, 4, 7, 10, 13, 16, 19, 22 and 25 post-operative days. The time
required for complete healing was also recorded.
Results: The res ults show that me an of surface ar e a of wound in all groups at the 1st da y
were similar. Surfa ce area in group IV at 4th, and 7th day was more than groups I (P < O.OOI)
and III (P |
|
| Keywords: Estradiol, Wound healing, Ovariocto my, Rat |
|
|
Full-Text [PDF 1528 kb]
(2193 Downloads)
|
Type of Study: Research |
Subject:
General
Received: 2008/12/30 | Published: 2002/02/15
|
|
|
|
|
|
|
| Add your comments about this article |
|
|
|
