اکثر مکاتبات کومش از طریق ایمیل سایت می باشد. لطفا Spam ایمیل خود را نیز چک نمایید.
   [Home ] [Archive]   [ فارسی ]  
:: ::
:: Volume 15, Issue 4 (تابستان 1393: 15 (4) 1393) ::
Koomesh 1393, 15(4): 522-529 Back to browse issues page
Effects of saffron aqueousextract and low frequency electromagnetic field on angiogenesison in a Wistar rat aortic ring model
Safa Moshtagh, Javad Baharara *, Saede Zafar-balanejad, Tayebe Ramezani
Abstract:   (5873 Views)
 Introduction: Angiogenesis is required for embryogenesis and many physiological and pathological conditions such as tumor growth. The effects of electromagnetic fields on cell development and growth have been investigated. In this experimental study, the synergic effects of saffron aqueous extract and low-frequency electromagnetic field on angiogenesis were investigated on rat aortic ring. Materials and Methods: In this experimental study, Wistar rat aorta was divided into pieces 1 mm and cultured in collagen matrices. On day 3, following observed sprouting angiogenesis the samples were classified into 8 groups: Control group, the first sham-exposed group (treated with PBS), the second sham-exposed group (treated with electromagnetic field off), and the third sham-exposed group treated with PBS and electromagnetic field off, the experimental groups 1 and 2 treated with 200 Gauss field for 2 hours and the concentrations of 200 and 300 µg/ml of saffron, respectively and the experimental groups 3 and 4 treated with 200 Gauss field for 3 hours and 200 and 300 µg/ml of saffron, respectively. All samples were photographed by invert microscope immediately and also 24 hours after the treatment. The number and length of vessels was determined by Image J software. Results: There was no significant differences between the control samples and the laboratory control samples 1, 2 and 3 with regards to average number and length of (P>0.05). However, the number of vessels in experimental groups 2 and 4 showed a significant reduction (P
Keywords: Angiogenesis inhibitors, Crocus, Aorta, Endothelial cells, Electromagnetic field, Rats
Full-Text [PDF 391 kb]   (1212 Downloads)    
Type of Study: Research | Subject: General
Received: 2013/10/31 | Accepted: 2014/04/13 | Published: 2014/06/11
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Moshtagh S, Baharara J, Zafar-balanejad S, Ramezani T. Effects of saffron aqueousextract and low frequency electromagnetic field on angiogenesison in a Wistar rat aortic ring model. Koomesh 1393; 15 (4) :522-529
URL: http://koomeshjournal.semums.ac.ir/article-1-2265-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 15, Issue 4 (تابستان 1393: 15 (4) 1393) Back to browse issues page
کومش Koomesh
Persian site map - English site map - Created in 0.04 seconds with 30 queries by YEKTAWEB 4540