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Orexin (hypocretin): A multi-functional hypothalamic peptide
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Mohammad Shabani   , Mohammad Mohammad-Zadeh , Hassan Azhdari-Zarmehri |
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Abstract: (15878 Views) |
| Hypocretins/orexins
are novel hypothalamic neuropeptides involved in various hypothalamic
mechanisms, such as energy homeostasis and neuroendocrine function. Orexins A
(33 amino acids) and B (28 amino acids) are derived from a single
pre-pro-orexin polypeptide. Physiological studies over the last ten years have
implicated orexin signaling plays a central role in a variety of important
biological processes. There is a clear evidence for defects in orexin signaling
being involved in obesity and diabetes, narcolepsy, panic anxiety disorder and
drug addiction. Therefore, this system may be a potentially important
therapeutic target for treatment of sleep disorder, obesity, emotional stress,
and addiction. In addtion, it has been well known that orexin-A elicits
analgesia. Thus, there is a considerable interest in the drug industry in the
development of potent compounds for the manipulation of orexin signaling. Therefore,
This a review about recent progress in understanding orexin system |
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| Keywords: Orexin (hypocretin), Hypothalamic peptide, Reward system, Obesity, Sleep disorder, Addiction |
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Full-Text [PDF 237 kb]
(4395 Downloads)
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Type of Study: Review |
Subject:
General
Received: 2012/11/29 | Accepted: 2013/12/17 | Published: 2014/03/10
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