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Activated leukocyte cell adhesion molecule expression in oral squamus cell carcinoma and its association with clinical and histopathologic parameters
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Omid میرمحمدخانی   , Pouriya مطهری , Alireza قنادان , Razieh چهاردهی , Majid میرمحمدخانی |
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Abstract: (11065 Views) |
| Introduction: The aim of the present research was to study the expression of
activated-leukocyte cell adhesion molecule (ALCAM) in oral squamus cell
carcinoma (OSCC) and its association with histopathological and prognostic
parameters. Materials and Methods: In a
cross-sectional study, samples of OSCC tumors from tongue and oral mucosa
available in Institute of Cancer of Imam Hospital in Tehran were simultaneously
studied in term of tumor size, lymph node metastasis, and differentiation and
ALCAM expression. Analysis was performed using multiple logistic regression
models. Results: 39
samples of tongue and 19 samples of oral medusa belonged to 35 men and 23 women
with mean (Standard deviation) of age 58(15.69) years of old were studied. More than half of lesions had good
differentiation and lymph node metastasis. From all, 42 (72.4%) of samples were
positive of ALCAM. Odds of ALCAM total expression in tumors with size of at
least 20 mm was more (OR=3.9, p=0.001). Odds ratios for membranous and
cytoplasmic expression of ALCAM in positive samples of lymph node metastasis
(OR=0.4, p=0.03) and in patients with age 40 and more (OR=2.7, p=0.002) were
respectively significant. Conclusion: The study confirmed positive
relationship between ALCAM expression and tumor size as while as ambiguity of
ALCAM role as a "Paradox" indicator. Next researches may make the
role of ALCAM in different phases of tumor developing clearer |
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| Keywords: Activated-Leukocyte cell adhesion molecule, Carcinoma, Squamous cell, Mouth neoplasms |
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Full-Text [PDF 228 kb]
(2521 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2012/06/4 | Accepted: 2013/04/8 | Published: 2013/04/8
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