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:: Volume 13, Issue 3 ((پياپي 43)، بهار 1391) ::
Koomesh 1391, 13(3): 368-375 Back to browse issues page
Effects of of 3,4-methylendioxymethamphetamine (ecstasy) on rat liver structure
Azam باقری حقیقی , Esmail فتاحی , Mohsen فروزانفر , Vahid حمایت خواه جهرمی
Abstract:   (15425 Views)
  Introduction: Ecstasy (methylendioxymethamphetamine) is a stimulant drug that has various side effects on nerve system, cardiovascular and immune system. This substance affects body tissues and can cause their death. Therefore, in the present study, we investigated the effects of ecstasy on liver tissues in Wistar rats.   Materials and Methods: Fifty Wistar rats, ranging 5-6 weeks of age, were divided into five groups (n=10) including control, sham, experimental 1, 2 and 3. In the experimental groups, the animals were injected with the consecutive doses of ecstasy (2, 4 and 8 mg/kg, I.P, for two weeks). The sham group received normal saline and the control group had no injection. Animals were sacrificed 12 hours after the latest injection of ecstasy. Liver tissues sections were provided and stained by hematoxylin-eosin to investigate the histopathological changes.   Results: Hepatocytes cells significantly decreased in experiment groups as compared with the control and sham groups (p
Keywords: Rats, 3, 4 methylenedioxyamphetamine (Ecstasy), Hepatocyt, Liver.
Full-Text [PDF 690 kb]   (2882 Downloads)    
Type of Study: Research | Subject: General
Received: 2011/04/18 | Accepted: 2011/10/30 | Published: 2012/04/15
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باقری حقیقی A, فتاحی E, فروزانفر M, حمایت خواه جهرمی V. Effects of of 3,4-methylendioxymethamphetamine (ecstasy) on rat liver structure . Koomesh 1391; 13 (3) :368-375
URL: http://koomeshjournal.semums.ac.ir/article-1-1285-en.html


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Volume 13, Issue 3 ((پياپي 43)، بهار 1391) Back to browse issues page
کومش Koomesh
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